Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene
Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene
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Evi-1 骨髓转化基因编码的锌指蛋白的鉴定、核定位和 DNA 结合活性
DOI：
10.1128/mcb.10.3.1259-1264.1990
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发表时间：
1990
影响因子：
5.3
通讯作者：
J. Ihle
中科院分区：
文献类型：
--
作者：
T. Matsugi;K. Morishita;J. Ihle
EVI-1锌指基因的激活是与小鼠髓系白血病转化相关的常见事件。为了鉴定该基因产物，我们研制了针对不同蛋白结构域的抗血清。这些抗血清主要检测到一个145千道尔顿的核蛋白与双链DNA结合。结合被络合剂抑制，被锌离子部分恢复。
Activation of the Evi-1 zinc finger gene is a common event associated with transformation of murine myeloid leukemias. To characterize the gene product, we developed antisera against various protein domains. These antisera primarily detected a 145-kilodalton nuclear protein that bound double-stranded DNA. Binding was inhibited by chelating agents and partially restored by zinc ions.
影响因子：
56.9
作者：
LEE, MS;GIPPERT, GP;WRIGHT, PE
通讯作者：
WRIGHT, PE
DOI：
10.1073/pnas.84.14.4841
发表时间：
1987-07-01
影响因子：
11.1
作者：
FRANKEL, AD;BERG, JM;PABO, CO
通讯作者：
PABO, CO