PROTON TRANSFER ACID-BASE CATALYSIS + ENZYMATIC HYDROLYSIS .I. ELEMENTARY PROCESSES
PROTON TRANSFER ACID-BASE CATALYSIS + ENZYMATIC HYDROLYSIS .I. ELEMENTARY PROCESSES
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DOI：
10.1002/anie.196400011
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发表时间：
1964-01-01
影响因子：
16.6
通讯作者：
EIGEN, M
中科院分区：
文献类型：
--
作者：
EIGEN, M
质子在溶液中发生的化学反应中作为促进剂和介体占有特殊的地位。有机化学中的许多反应是由酸或碱催化的;同样，大多数酶含有促进酸碱催化的活性基团。为了理解所涉及的反应机制，有必要确定基本步骤以及它们的时间过程。只有随着研究超快反应的新方法的发展，才有可能对这些基本步骤进行系统的研究。本文回顾了此类调查中获得的信息。其结果是一个相对完整的图片基本质子转移机制和酸碱和酶催化的模式和规律的全面描述。
The proton occupies a special position as a promoter and mediator in chemical reactions occurring in solution. Many reactions in organic chemistry are catalysed by acids or bases; likewise, most enzymes contain active groups which promote acid-base catalysis. To understand the reaction mechanisms involved, it is necessary to identify the elementary steps as well as their course in time. Systematic investigation of these elementary steps has become possible only with the development of new methods for studying very fast reactions. The present paper reviews the information obtained in this type of investigation. The result is a relatively complete picture of the elementary proton transfer mechanisms and a comprehensive description of the modes and laws of acid-base and enzymatic catalysis.