COMPARISON OF MORPHOLOGIC FINDINGS IN SPONTANEOUSLY OCCURRING HYPERTROPHIC CARDIOMYOPATHY IN HUMANS, CATS AND DOGS
COMPARISON OF MORPHOLOGIC FINDINGS IN SPONTANEOUSLY OCCURRING HYPERTROPHIC CARDIOMYOPATHY IN HUMANS, CATS AND DOGS
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DOI：
10.1016/0002-9149(93)91112-u
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发表时间：
1993-10-15
影响因子：
2.8
通讯作者：
MARON, BJ
中科院分区：
文献类型：
--
作者：
LIU, SK;ROBERTS, WC;MARON, BJ
比较了38例人、51只猫和10只狗自发性肥厚型心肌病(HC)的形态特征。室间隔不对称性肥厚、明显的心肌细胞紊乱、壁内冠状动脉异常和心肌纤维化分别存在于人、猫和犬型HC的室间隔；这些异常通常在人类中更严重和最常见。与猫(16/51[31%])相比，不对称性左心室肥厚(基于计算的室间隔与游离壁厚比)最常见于人类(31/38[81%])和狗(8/10[80%])。
Morphologic features of spontaneously occurring hypertrophic cardiomyopathy (HC) were compared in 38 humans, 51 cats and 10 dogs. Asymmetric hypertrophy of the ventricular septum, marked disorganization ot cardiac muscle cells, abnormal intramural coronary arteries and myocardial fibrosis were each present in the ventricular septum of human, feline, and canine forms of HC; these abnormalities were generally more severe and most frequently identified in humans. Asymmetric left ventricular hypertrophy (based on the calculated septal-to-free wall thickness ratio) was most common in humans (31 of 38 [81%]) and dogs (8 of 10 [80%]), as compared with cats (16 of 51 [31%]; p