Genetic diversity of H9N2 influenza viruses from pigs in China: A potential threat to human health?
Genetic diversity of H9N2 influenza viruses from pigs in China: A potential threat to human health?
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DOI：
10.1016/j.vetmic.2010.11.008
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发表时间：
2011-04-21
影响因子：
3.3
通讯作者：
Tong, Guang-Zhi
中科院分区：
文献类型：
--
作者：
Yu, Hai;Zhou, Yan-Jun;Tong, Guang-Zhi
甲型流感病毒的大流行毒株可能是由来自不同宿主的病毒之间的基因重组引起的。猪对人流感病毒和禽流感病毒都很敏感，并被认为是通过重组或适应哺乳动物宿主产生大流行性流感病毒的中间宿主或混合容器。另外8个基因型（C-J）病毒可能是双重组病毒，其中6个基因型（E-J）病毒具有1-4个H5样基因片段，表明它们是H9和H5病毒的重组病毒。综上所述，中国猪源H9N2流感病毒的遗传多样性进一步证明了H9N2病毒确实发生过禽到猪的种间传播，并可能通过与猪H1N1、H1N2和H3N2流感病毒的基因重组产生新的重组病毒，因此，这些猪H9N2流感病毒可能对人类健康构成潜在威胁，在中国继续开展猪流感病毒监测具有重要意义。(C) 2010 Elsevier B.V.版权所有
Pandemic strains of influenza A virus might arise by genetic reassortment between viruses from different hosts. Pigs are susceptible to both human and avian influenza viruses and have been proposed to be intermediate hosts or mixing vessels, for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we summarize and report for the first time the coexistence of 10 (A-J) genotypes in pigs in China by analyzing the eight genes of 28 swine H9N2 viruses isolated in China from 1998 to 2007. Swine H9N2 viruses in genotype A and B were completely derived from Y280-like and Shanghai/F/98-like viruses, respectively, which indicated avian-to-pig interspecies transmission of H9N2 viruses did exist in China. The other eight genotype (C-J) viruses might be double-reassortant viruses, in which six genotype (E-J) viruses possessed 1-4 H5-like gene segments indicating they were reassortants of H9 and H5 viruses. In conclusion, genetic diversity of H9N2 influenza viruses from pigs in China provides further evidence that avian to pig interspecies transmission of H9N2 viruses did occur and might result in the generation of new reassortant viruses by genetic reassortment with swine H1N1, H1N2 and H3N2 influenza viruses, therefore, these swine H9N2 influenza viruses might be a potential threat to human health and continuing to carry out swine influenza virus surveillance in China is of great significance. (C) 2010 Elsevier B.V. All rights reserved.