Influences of microbiota on intestinal immune system development
Influences of microbiota on intestinal immune system development
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DOI：
10.1093/ajcn/69.5.1046s
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发表时间：
1999-05-01
影响因子：
7.1
通讯作者：
Cebra, JJ
中科院分区：
文献类型：
--
作者：
Cebra, JJ
据推测，共生微生物在哺乳动物肠道的正常定植可以驱动新生儿期间体液和细胞粘膜免疫系统的发育，并在整个生命过程中维持肠道炎症的生理正常稳定状态。使用传统饲养的新生小鼠和无菌、故意定植的成年小鼠（限生小鼠）来检查某些肠道微生物的功效。
The normal colonization of the mammalian intestine with commensal microbes is hypothesized to drive the development of the humoral and cellular mucosal immune systems during neonatal life and to maintain the physiologically normal steady state of inflammation in the gut throughout life. Neonatal conventionally reared mice and germ-free, deliberately colonized adult mice (gnotobiotic mice) were used to examine the efficacy of certain intestinal microbes.