Transplant tumor registry: Donor related malignancies
Transplant tumor registry: Donor related malignancies
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DOI：
10.1097/00007890-200208150-00011
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发表时间：
2002-08-15
期刊：
影响因子：
6.2
通讯作者：
Roza, AM
中科院分区：
文献类型：
--
作者：
Kauffman, HM;McBride, MA;Roza, AM
背景从临床移植的早期开始，供体恶性肿瘤的传播就有间歇性的报道。美国供体相关恶性肿瘤的发病率以前没有记录。从1994年4月1日至2001年7月1日，在34，933名尸体供体和108，062名受体的队列中，对报告给器官获取和移植网络/器官共享联合网络的所有供体相关恶性肿瘤进行了调查，通过联系移植中心来验证报告的肿瘤是否来自供体。确定了发现的时间和方式，以及移植物和患者的结局。对供者的其他受者的情况进行调查。共报告了21例供体相关恶性肿瘤，来自14例尸体和3例活体供体。15个肿瘤是供体传播的，6个是供体来源的。转移性肿瘤是移植时供体体内存在的恶性肿瘤。衍生肿瘤是在移植后在移植的供体造血或淋巴细胞中发展的新生肿瘤。尸体供者相关肿瘤发生率为0.04%（14/34，993）。供者相关肿瘤发生率为0.017%（18/108，062）。在发生供者相关恶性肿瘤的患者中，总死亡率为38%，其中转移性肿瘤为46%，衍生性肿瘤为33%。尸体供者相关肿瘤死亡率为0.007%（8/108，062）。美国供体相关肿瘤的发病率非常低。与供体相关的肿瘤死亡率也非常低，特别是与等待名单的死亡率相比。
Background. Transmission of donor malignancies has been intermittently reported since the early days of clinical transplantation. The incidence of United States donor related malignancies has not previously been documented.Methods. All donor related malignancies reported to the Organ Procurement and Transplantation Network/United Network for Organ Sharing from 4/1/94-7/1/01 in a cohort of 34,933 cadaveric donors and 108,062 recipients were investigated by contacting the transplant centers to verify that the reported tumors were of donor origin. Time and mode of discovery, as well as graft and patient outcome, were determined. The status of other recipients from the donor was investigated.Results. A total of 21 donor related malignancies from 14 cadaveric and 3 living donors were reported. Fifteen tumors were donor transmitted and 6 were donor derived. Transmitted tumors are malignancies that existed in the donor at the time of transplantation. Derived tumors are de novo tumors that develop in transplanted donor hematogenous or lymphoid cells after transplantation. The cadaveric donor related tumor rate is 0.04% (14 of 34,993). The donor related tumor rate among transplanted cadaveric organs is 0.017% (18 of 108,062). Among patients developing donor related malignancies, the overall mortality rate was 38%, with that of transmitted tumors being 46% and derive tumors being 33%. The cadaveric donor related tumor mortality rate is 0.007% (8 of 108,062).Conclusions. The United States incidence of donor related tumors is extremely small. The donor related tumor death rate is also extremely small, particularly when compared with waiting-list mortality.