Vitamin C Requirements in Parenteral Nutrition
Vitamin C Requirements in Parenteral Nutrition
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DOI：
10.1053/j.gastro.2009.08.012
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发表时间：
2009-11-01
期刊：
影响因子：
29.4
通讯作者：
Berger, Mette M.
中科院分区：
文献类型：
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作者：
Berger, Mette M.
维生素 C 的一些生化功能使其成为肠外营养 (PN) 的重要组成部分，也是其他急性病症的重要治疗补充剂。抗坏血酸是一种强效的水性抗氧化剂，并且是多种酶的辅助因子。维生素C的平均体内储备量为1.5克，其中每天使用3%-4%（40-60毫克）。非吸烟者的剂量为 60 mg/d，吸烟者的剂量为 140 mg/d，可维持稳定状态。受到休克的手术、创伤和脓毒症患者的循环血浆抗坏血酸浓度急剧降低。这些低浓度需要每天 3 克剂量才能恢复正常的血浆抗坏血酸浓度，这对 100 毫克/天的推荐 PN 剂量提出了质疑。静脉注射需要量的确定通常基于血浆浓度，血浆浓度在炎症反应过程中会发生变化。没有明确的缺乏指标：血清或血浆抗坏血酸浓度
Some biochemical functions of vitamin C make it an essential component of parenteral nutrition (PN) and an important therapeutic supplement in other acute conditions. Ascorbic acid is a strong aqueous antioxidant and is a cofactor for several enzymes. The average body pool of vitamin C is 1.5 g, of which 3%-4% (40-60 mg) is used daily. Steady state is maintained with 60 mg/d in nonsmokers and 140 mg/d in smokers. Shocked surgical, trauma, and septic patients have a drastic reduction of circulating plasma ascorbate concentrations. These low concentrations require 3-g doses/d to restore normal plasma ascorbate concentrations, questioning the recommended PN dose of 100 mg/d. Determination of intravenous requirements is usually based on plasma concentrations, which are altered during the inflammatory response. There is no clear indicator of deficiency: serum or plasma ascorbate concentrations