Hypergastrinemia--a risk factor for myocardial infarction?
Hypergastrinemia--a risk factor for myocardial infarction?
复制标题
高胃泌素血症——心肌梗塞的危险因素？
DOI：
10.1093/clinchem/31.4.585
复制
发表时间：
1985
影响因子：
9.3
通讯作者：
E. Nyström
中科院分区：
文献类型：
--
作者：
G. Lindstedt;C. Bengtsson;L. Lapidus;E. Nyström
我们测定了1968-69年间256名妇女（175名54岁妇女和81名60岁妇女）血清中的胃泌素和胃蛋白酶原I。12年随访中血清胃泌素浓度与心肌梗死发生率显著（p < 0.01）正相关，多因素分析中考虑年龄作为背景变量。它与总体死亡率或12年心绞痛发病率、表明缺血性心脏病的心电图变化或中风无关。与心肌梗死的相关性与吸烟、收缩压、肥胖指数、空腹血糖、血清甘油三酯和胆固醇浓度以及筛查或随访时是否存在糖尿病无关。血清胃泌素与体重指数呈正相关（p < 0.05），与吸烟呈负相关（p < 0.05）。这些发现可能为心肌梗死危险因素的分析提供一个新的视角。
We determined gastrin and pepsinogen I in serum samples obtained in 1968-69 from 256 women (175 women 54 years old and 81 women 60 years old when sampled). The concentration of gastrin in serum was significantly (p less than 0.01) and positively correlated with the incidence of myocardial infarction during a 12-year follow-up, with age taken into account as a background variable in multivariate analysis. It was not correlated with overall mortality or with the 12-year incidences of angina pectoris, electrocardiographic changes indicating ischemic heart disease, or stroke. The correlation with myocardial infarction was independent of smoking, systolic blood pressure, indices of obesity, concentrations of blood glucose during fasting and of serum triglycerides and cholesterol, and of the presence of diabetes mellitus at screening or during follow-up. Serum gastrin was significantly (p less than 0.05) related to body mass index (positive age-specific relation) and to smoking (negative age-specific relation). These findings may provide a new aspect to analysis of risk factors for myocardial infarction.