PGC-1 coactivators in cardiac development and disease.
PGC-1 coactivators in cardiac development and disease.
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DOI：
10.1161/circresaha.110.223818
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发表时间：
2010-10-01
影响因子：
20.1
通讯作者：
Arany Z
中科院分区：
文献类型：
--
作者：
Rowe GC;Jiang A;Arany Z
跳动的心脏需要持续的ATP流量来维持收缩功能，越来越多的证据表明，能量缺陷有助于心力衰竭的发展。在过去的十年里，人们对心脏中间代谢的兴趣重新燃起，对调节心脏能量学的转录网络的理解也急剧增加。PPAR-gamma coactivator（PGC）-1蛋白家族在这些通路中起着核心作用。PGC-1蛋白调节转录网络的机制，并通过生理线索进行调节，以及它们在心脏发育和疾病中所起的作用，在这里进行了综述。
The beating heart requires a constant flux of ATP to maintain contractile function, and there is increasing evidence that energetic defects contribute to the development of heart failure. The last ten years have seen a resurgent interest in cardiac intermediary metabolism, and a dramatic increase in our understanding of transcriptional networks that regulate cardiac energetics. The PPAR-gamma coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological cues, and the roles they play in cardiac development and disease, are reviewed here.