Relationships between the extent of apnea-induced bradycardia and thevascular response in the arm and leg during dynamic two-legged knee extension exercise.
Relationships between the extent of apnea-induced bradycardia and thevascular response in the arm and leg during dynamic two-legged knee extension exercise.
复制标题
动态双腿膝关节伸展运动中呼吸暂停引起的心动过缓程度与手臂和腿部血管反应之间的关系。
DOI：
10.1152/ajpheart.00413.2011
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Ichinose M.
中科院分区：
文献类型：
--
作者：
Nishiyasu T;Tsukamoto R;Kawai K;Hayashi K;Koga S;Ichinose M.
我们的目的是检验这样的假设：人类动态运动期间呼吸暂停引起的血流动力学反应在表现出强烈心动过缓的人和仅表现出轻度心动过缓的人之间存在差异。在评估动态运动期间呼吸暂停引起的心率（HR）变化后，选择23名健康受试者并分为大反应组（L组；n=11）和小反应组（S组；n=12）。当受试者在心率增加 30 次/分钟的工作负荷下进行两腿动态膝关节伸展运动时，测量呼吸暂停引起的心率变化、心输出量 (CO)、平均动脉压 (MAP)、动脉氧饱和度 (SaO2)、前臂血流量 (FBF) 和腿部血流量 (LBF)。呼吸暂停时，L组HR（54±2次/min）低于S组（92±3次/min，P<0.05）。两组 CO、SaO2、FBF、LBF、前臂血管电导（FVC）、下肢血管电导（LVC）和总血管电导（TVC）均降低，MAP 升高，但 L 组 CO、TVC、LBF、LVC 和 MAP 变化大于 S 组（P<0.05）。此外，HR 的降低与 TVC、LVC 和 FVC 的降低之间存在显着的正线性关系。我们得出的结论是，在运动过程中表现出更大的呼吸暂停引起的心动过缓的个体在活跃和不活跃的肌肉区域也表现出更大的血管收缩。
Our aim was to test the hypothesis that apnea-induced hemodynamic responses during dynamic exercise in humans differ between those who show strong bradycardia and those who show only mild bradycardia. After apnea-induced changes in heart rate (HR) were evaluated during dynamic exercise, 23 healthy subjects were selected and divided into a large response group (L group;n= 11) and a small response group (S group;n= 12). While subjects performed a two-legged dynamic knee extension exercise at a work load that increased HR by 30 beats/min, apnea-induced changes in HR, cardiac output (CO), mean arterial pressure (MAP), arterial O2saturation (SaO2), forearm blood flow (FBF), and leg blood flow (LBF) were measured. During apnea, HR in the L group (54 ± 2 beats/min) was lower than in the S group (92 ± 3 beats/min,P< 0.05). CO, SaO2, FBF, LBF, forearm vascular conductance (FVC), leg vascular conductance (LVC), and total vascular conductance (TVC) were all reduced, and MAP was increased in both groups, although the changes in CO, TVC, LBF, LVC, and MAP were larger in the L group than in the S group (P< 0.05). Moreover, there were significant positive linear relationships between the reduction in HR and the reductions in TVC, LVC, and FVC. We conclude that individuals who show greater apnea-induced bradycardia during exercise also show greater vasoconstriction in both active and inactive muscle regions.