Auxin Response Factors — output control in auxin biology
Auxin Response Factors — output control in auxin biology
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DOI：
10.1101/129122
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发表时间：
2017-04
期刊：
影响因子：
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通讯作者：
Mark Roosjen;Sébastien Paque;D. Weijers
中科院分区：
文献类型：
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作者：
Mark Roosjen;Sébastien Paque;D. Weijers
植物激素生长素几乎参与了陆地植物的所有发育过程。这些过程中的大多数，如果不是全部的话，都是通过基因表达的变化来调节的。生长素通过一条短的核途径作用于基因的表达，该途径在DNA结合转录因子家族的激活时汇聚。因此，这些生长素反应因子(ARF)是生长素反应的效应器，并将化学信号翻译成对一组特定基因的调节。由于生长素信号中的专用成分数量有限，ARF家族之间的不同特性可能有助于在植物发育过程中建立多种独特的生长素反应。在拟南芥中发现第一个ARF之后的二十年里，关于这些转录因子是如何作用的，以及它们是如何产生独特的生长素反应的，人们已经了解了很多。遗传学、生物化学、基因组学和结构生物学方面的进展有助于开发ARF作用的机制模型。然而，尽管作出了密集的努力，许多核心问题仍有待解决。在这篇综述中，我们重点介绍了有关ARF转录因子的知识，并确定了在不久的将来存在的突出问题和挑战。
The phytohormone auxin is involved in almost all developmental processes in land plants. Most, if not all, of these processes are mediated by changes in gene expression. Auxin acts on gene expression through a short nuclear pathway that converges upon the activation of a family of DNA-binding transcription factors. These AUXIN RESPONSE FACTORS (ARFs) are thus the effector of auxin response and translate the chemical signal to the regulation of a defined set of genes. Given the limited number of dedicated components in auxin signaling, distinct properties among the ARF family likely contributes to the establishment of multiple unique auxin responses in plant development. In the two decades following the identification of the first ARF in Arabidopsis much has been learnt about how these transcription factors act, and how they generate unique auxin responses. Progress in genetics, biochemistry, genomics and structural biology have helped to develop mechanistic models for ARF action. However, despite intensive efforts, many central questions are yet to be addressed. In this review we highlight what has been learnt about ARF transcription factors, and identify outstanding questions and challenges for the near future.