Differing effect of chenodeoxycholic acid and ursodeoxycholic acid on bile acids in rat colonic wall and contents.
Differing effect of chenodeoxycholic acid and ursodeoxycholic acid on bile acids in rat colonic wall and contents.
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鹅去氧胆酸和熊去氧胆酸对大鼠结肠壁胆汁酸及其内容物的不同影响。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
U. Leuschner
中科院分区：
文献类型：
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作者：
W. Kurtz;S. Guldutuna;U. Leuschner
胆汁酸可能会促进实验性结肠癌。许多研究都将粪便胆汁酸与结直肠癌联系起来。关于结肠粘膜中的胆汁酸及其与管腔胆汁酸的关系，人们知之甚少。因此，我们研究了正常雌性Wistar大鼠结肠壁的胆汁酸和胆汁酸的含量，以及给药后14天鹅去氧胆酸或熊去氧胆酸(90 mg/kg/d)两种胆汁酸的药用溶石作用。两种方案都会增加结肠内容物中的总胆汁酸，熊去氧胆酸会产生更高的毒性胆石酸。在结肠壁中，只有熊去氧胆酸会导致包括石胆酸在内的大多数非硫酸盐胆汁酸的增加。结肠壁的胆汁酸类型与内容物无相关性。我们得出结论，在人类服用熊去氧胆酸后，结肠壁胆汁酸的增加需要控制。在未来的结直肠癌研究中，不仅是粪便，而且粘膜胆汁酸浓度应该与癌变相关。
Bile acids may promote experimental colonic cancer. Many studies correlate fecal bile acids and colorectal carcinomas. Little is known on bile acids in the colonic mucosa and their relation to luminal bile acids. We, therefore, studied bile acids in colonic wall and contents of normal female Wistar rats and after 14 days' administration of chenodeoxycholic acid or ursodeoxycholic acid (90 mg/kg daily), two bile acids used in medicamentous cholelitholysis. Both regimens increase total bile acids in colonic contents, ursodeoxycholic acid produces a higher rise in toxic lithocholic acid. In the colonic wall, only ursodeoxycholic acid causes an increase of most nonsulfated bile acids including lithocholic acid. Bile acid patterns do not correlate in colonic wall and contents. We conclude that increased colonic wall bile acids after ursodeoxycholic acid administration warrant control in man. In future colorectal carcinoma studies, not only fecal, but also mucosal bile acid concentrations should be correlated to carcinogenesis.