The critical roles of serum/glucocorticoid-regulated kinase 3 (SGK3) in the hair follicle morphogenesis and homeostasis: the allelic difference provides novel insights into hair follicle biology.
The critical roles of serum/glucocorticoid-regulated kinase 3 (SGK3) in the hair follicle morphogenesis and homeostasis: the allelic difference provides novel insights into hair follicle biology.
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DOI：
10.2353/ajpath.2006.050507
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发表时间：
2006-04
期刊：
影响因子：
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通讯作者：
Taro Okada;Y. Ishii;K. Masujin;A. Yasoshima;J. Matsuda;A. Ogura;H. Nakayama;T. Kunieda;K. Doi-K.
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文献类型：
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作者：
Taro Okada;Y. Ishii;K. Masujin;A. Yasoshima;J. Matsuda;A. Ogura;H. Nakayama;T. Kunieda;K. Doi-K.
血清/糖皮质激素调节激酶3（Sgk 3，也称为Sgkl或Cisk）基因突变导致小鼠毛囊发育缺陷和毛发周期改变。我们检查了Sgk 3突变型YPC小鼠（YPC-Sgk 3（ypc）/Sgk 3（ypc）），发现SGK 3蛋白表达功能改变。在YPC小鼠的毛囊中，由于生后毛囊发育过程中毛基质角质形成细胞的分化异常和增殖能力低下，导致毛髓质完全缺失，毛发稀疏。令人惊讶的是，出生后毛囊发育和生长期的长度显着缩短。此外，GSK 3 β在Ser 9的磷酸化和β-catenin的核积累在发育中的YPC毛囊中减少，这表明GSK 3 β和WNT-β-catenin通路的磷酸化参与了SGK 3依赖的毛囊发育调节。此外，上述特征，特别是毛发循环模式，不同于其他Sgk 3缺失突变株，表明SGK 3蛋白功能障碍的各种模式可能导致表型变异。我们的研究结果表明，SGK 3是一个非常重要的和特征性的分子，在毛囊形态发生和毛发周期中起着关键作用。
Mutation in the serum/glucocorticoid regulated kinase 3 (Sgk3, also known as Sgkl or Cisk) gene causes both defective hair follicle development and altered hair cycle in mice. We examined Sgk3-mutant YPC mice (YPC-Sgk3(ypc)/Sgk3(ypc)) and found expression of SGK3 protein with altered function. In the hair follicles of YPC mice, the aberrant differentiation and poor proliferation of hair matrix keratinocytes during the period of postnatal hair follicle development resulted in a complete lack of hair medulla and weak hair. Surprisingly, the length of postnatal hair follicle development and anagen term was shown to be dramatically shortened. Also, phosphorylation of GSK3beta at Ser9 and the nuclear accumulation of beta-catenin were reduced in the developing YPC hair follicle, suggesting that phosphorylation of GSK3beta and WNT-beta-catenin pathway takes part in the SGK3-dependent regulation of hair follicle development. Moreover, the above-mentioned features, especially the hair-cycling pattern, differ from those in other Sgk3-null mutant strains, suggesting that the various patterns of dysfunction in the SGK3 protein may result in phenotypic variation. Our results indicate that SGK3 is a very important and characteristic molecule that plays a critical role in both hair follicle morphogenesis and hair cycling.