Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines.
Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines.
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DOI：
10.1080/07853890.2022.2031274
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发表时间：
2022-12
影响因子：
4.4
通讯作者：
Dermime S
中科院分区：
文献类型：
--
作者：
Fernandes Q;Inchakalody VP;Merhi M;Mestiri S;Taib N;Moustafa Abo El-Ella D;Bedhiafi T;Raza A;Al-Zaidan L;Mohsen MO;Yousuf Al-Nesf MA;Hssain AA;Yassine HM;Bachmann MF;Uddin S;Dermime S
在过去的几个月里，SARS-CoV-2的新变种的出现突出了诊断，治疗以及针对该病毒的疫苗开发的主要挑战之一。SARS-CoV-2检测的进展包括基于核酸、基于抗原和免疫测定以及基于抗体的检测方法，以实现高效、稳健和快速的检测;而COVID-19预防和治疗策略的进展包括新型抗病毒和免疫调节药物以及SARS-CoV-2靶向疫苗。不同的COVID-19疫苗平台和每种疫苗诱导的免疫反应以及它们对抗接种后感染的能力都在这篇综述中进行了讨论。SARS-CoV-2的新的和不断发展的变体的出现促进了对检测SARS-CoV-2感染的更新和更适应性的诊断方法的形式的改变的需要。另一方面，由于新出现的变异和感染个体中表现出的不同症状，开发快速和敏感的诊断技术现在更具挑战性。除此之外，疫苗仍然是预防和保护免受感染的主要支柱。新的疫苗和药物正在不断开发，以释放针对SARS-CoV-2及其相关变体的强大靶向免疫应答。在这篇综述中，我们提供了一个更新的视角，目前的挑战所带来的新的SARS-CoV-2突变体/变异体的出现和诊断技术的发展，使他们的检测。此外，我们还讨论了一些最常用的疫苗/治疗药物的开发，配方，工作机制，优点和缺点及其随后的免疫影响。
The emergence of novel variants of the SARS-CoV-2 in the past couple of months, highlights one of the primary challenges in the diagnostics, treatment, as well as vaccine development against the virus. Advancements in SARS-CoV-2 detection include nucleic acid based, antigen and immuno- assay-based and antibody-based detection methodologies for efficient, robust, and quick testing; while advancements in COVID-19 preventive and therapeutic strategies include novel antiviral and immunomodulatory drugs and SARS-CoV-2 targeted vaccines. The varied COVID-19 vaccine platforms and the immune responses induced by each one of them as well as their ability to battle post-vaccination infections have all been discussed in this review. The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing rapid and sensitive diagnostic technologies is now more challenging due to emerging variants and varying symptoms exhibited among the infected individuals. In addition to this, vaccines remain the major mainstay of prevention and protection against infection. Novel vaccines and drugs are constantly being developed to unleash an immune response for the robust targeting of SARS-CoV-2 and its associated variants. In this review, we provide an updated perspective on the current challenges posed by the emergence of novel SARS-CoV-2 mutants/variants and the evolution of diagnostic techniques to enable their detection. In addition, we also discuss the development, formulation, working mechanisms, advantages, and drawbacks of some of the most used vaccines/therapeutic drugs and their subsequent immunological impact.
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DOI：
10.1016/j.ijid.2021.10.005
发表时间：
2021-12
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Giovacchini N;Coppi M;Aiezza N;Baccani I;Malentacchi F;Pollini S;Antonelli A;Rossolini GM
通讯作者：
Rossolini GM
影响因子：
13.2
作者：
Chan, Jasper Fuk-Woo;Kok, Kin-Hang;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
10
作者：
Chu, CM;Cheng, VCC;Yuen, KY
通讯作者：
Yuen, KY