Perception of microstimulation frequency in human somatosensory cortex.
Perception of microstimulation frequency in human somatosensory cortex.
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DOI：
10.7554/elife.65128
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发表时间：
2021-07-27
期刊：
影响因子：
7.7
通讯作者：
Gaunt RA
中科院分区：
文献类型：
--
作者：
Hughes CL;Flesher SN;Weiss JM;Boninger M;Collinger JL;Gaunt RA
体感皮层中的微刺激可以唤起人工触觉感知，并可以被纳入双向脑机接口（BCI），以恢复受伤或疾病后的功能。然而，很少有人知道刺激参数本身如何影响感知。在这里，我们通过微电极阵列植入在两个人类参与者与颈脊髓损伤的体感皮层刺激和不同的刺激幅度，频率和训练持续时间。增加幅度和训练持续时间增加了所有测试电极上的感知强度。令人惊讶的是，我们发现增加频率在某些电极上引起更强烈的感知，但在其他电极上引起不太强烈的感知。这些不同的频率-强度关系被分为三组，它们在不同的刺激频率下也诱发了不同的记忆质量。相邻电极部位更可能属于同一组。这些结果支持这样的想法，刺激频率直接控制触觉感知，这些不同的感知可能与体感皮层的组织，这将有利于原则性的发展刺激策略的双向脑机接口。
Microstimulation in the somatosensory cortex can evoke artificial tactile percepts and can be incorporated into bidirectional brain–computer interfaces (BCIs) to restore function after injury or disease. However, little is known about how stimulation parameters themselves affect perception. Here, we stimulated through microelectrode arrays implanted in the somatosensory cortex of two human participants with cervical spinal cord injury and varied the stimulus amplitude, frequency, and train duration. Increasing the amplitude and train duration increased the perceived intensity on all tested electrodes. Surprisingly, we found that increasing the frequency evoked more intense percepts on some electrodes but evoked less-intense percepts on other electrodes. These different frequency–intensity relationships were divided into three groups, which also evoked distinct percept qualities at different stimulus frequencies. Neighboring electrode sites were more likely to belong to the same group. These results support the idea that stimulation frequency directly controls tactile perception and that these different percepts may be related to the organization of somatosensory cortex, which will facilitate principled development of stimulation strategies for bidirectional BCIs.