Stress-related sleep disturbance and poly somnographic response to caffeine
Stress-related sleep disturbance and poly somnographic response to caffeine
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DOI：
10.1016/j.sleep.2006.03.019
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发表时间：
2006-10-01
期刊：
影响因子：
4.8
通讯作者：
Roth, Thomas
中科院分区：
文献类型：
--
作者：
Drake, Christopher L.;Jefferson, Catherine;Roth, Thomas
背景和目的：通过多导睡眠描记仪测定易受压力相关睡眠障碍影响的个体对咖啡因的睡眠反应。患者和方法：11名没有失眠的健康人得分较低（4名女性，平均年龄= 32.64 +/- 15.46岁）和10名健康人也没有失眠评分高（6名女性，平均年龄=34.20 +/- 13.73岁）对压力相关睡眠障碍的脆弱性的测量在实验室协议中进行了研究。在熄灯前1小时给予中低剂量的咖啡因（3 mg/kg），并与平衡控制夜晚进行比较，每种条件间隔1周。标准的多导睡眠图的措施进行了评估（即总睡眠时间，睡眠效率，持续睡眠的潜伏期，睡眠阶段的百分比）为控制和咖啡因nights.Results：有没有组间差异，在控制晚上的睡眠。重要的是，报告易受压力相关睡眠障碍影响的个体对咖啡因挑战的持续睡眠的潜伏期显著延长（相互作用; P
Background and purpose: To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography.Patients and methods: Eleven healthy individuals without insomnia scoring low (4 women, mean age= 32.64 +/- 15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20 +/- 13.73 years) on a measure of vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights.Results: There were no between-group differences in sleep on the control night. Importantly, individuals reporting vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P