Effect of Hemodialysis and Diet on the Exhaled Breath Methanol Concentration in Patients With ESRD
Effect of Hemodialysis and Diet on the Exhaled Breath Methanol Concentration in Patients With ESRD
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DOI：
10.1053/j.jrn.2011.07.003
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发表时间：
2012-05-01
影响因子：
3.2
通讯作者：
Blake, Donald R.
中科院分区：
文献类型：
--
作者：
Lee, Hyun Ji (Julie);Pahl, Madeleine V.;Blake, Donald R.
目的：终末期肾病（ESRD）会导致含氮废物的积累以及酸碱、矿物质、液体和电解质紊乱，这些都可以通过血液透析（HD）得到部分纠正。虽然ESRD和透析对体液成分的影响是众所周知的，但对呼气成分的影响尚不确定。甲醇是由结肠微生物组从不可吸收的复合碳水化合物产生的。旨在限制钾摄入量的水果和蔬菜的饮食限制降低了膳食纤维的摄入量;减少的纤维摄入量反过来又会减少甲醇的产生及其在呼出气中的出现。在这项研究中，我们调查了呼吸甲醇levels.Design和方法：10个终末期肾病患者在HD过程中，在3和2天的透析间期的变化。在每种情况下，使用真空罐收集20份呼出气和室内空气样本。10名年龄匹配的正常人作为对照。结果：7例肾性饮食的ESRD患者的甲醇浓度（90 ± 29 ppbv）低于3例高纤维饮食的患者（340 ± 48 ppbv，P
Objectives: End-stage renal disease (ESRD) causes accumulation of nitrogenous waste products and acid-base, mineral, fluid, and electrolyte disorders, which are partially corrected by hemodialysis (HD). While the effects of ESRD and dialysis on body fluid composition are well known, the effects on composition of expired breath are uncertain. Methanol is produced from unabsorbable complex carbohydrates by the colonic microbiome. Dietary restrictions of fruits and vegetables aimed at limiting potassium intake lower the intake of dietary fibers; the reduced fiber intake can in turn reduce production of methanol and its appearance in the exhaled breath. In this study, we investigated the inter-and intradialytic changes in the breath methanol levels.Design and Method: Ten ESRD patients were studied during HD procedures at 3- and 2-day interdialytic intervals. On each occasion, 20 exhaled breath and room air samples were collected using evacuated canisters. Ten age-matched normal subjects served as controls. The samples were analyzed on a unique 6-column/detector gas chromatography system.Results: Seven ESRD patients consuming renal diet had lower methanol concentration (90 +/- 29 ppbv) than the 3 patients consuming high-fiber diet (340 +/- 48 ppbv, P