Changes in Genetic and Enzymatic Inhibiting Effects of Organophosphorus Pesticides during Aqueous Chlorination
Changes in Genetic and Enzymatic Inhibiting Effects of Organophosphorus Pesticides during Aqueous Chlorination
复制标题
有机磷农药在水氯化过程中遗传和酶抑制作用的变化
DOI：
10.5985/jec.5.65
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
S. Ishikura
中科院分区：
文献类型：
--
作者：
S. Onodera;Y. Hirose;S. Ishikura
氯被广泛用作水处理和食品工业中的消毒剂。因此，五种有机磷农药（EPN，二嗪农，杀螟硫磷，马拉硫磷和敌敌畏），进行了水氯化与次氯酸盐的胆碱酯酶（ChE）活性的抑制作用和这些反应产物的致突变性的评价。用次氯酸盐处理硫代磷（P=S）农药溶液，可产生对胆碱酯酶（ChE）活性有很大抑制作用的化合物，但进一步反应会导致ChE抑制活性的降低。这些P=S化合物溶液的次氯酸盐氯化水溶液也被证明产生对S具有致突变性的化合物。不含S9混合物的伤寒沙门氏菌TA 98。诱变剂的产生取决于母体农药、溶液pH值和反应时间。
Chlorine is widely used as a disinfectant in water treatment and in the food industry. Five organophosphorus pesticides (EPN, diazinon, fenitrothion, malathion and parathion) were, therefore, subjected to aqueous chlorination with hypochlorite to evaluate inhibitory effect on cholinesterase (ChE) activity and mutagenic effect of these reaction products. Treatment with hypochlorite of thiophosphorus (P=S) pesticide solutions was shown to produce compounds with a great inhibiting effect on ChE activity, but, further reactions resulted in decrease in the ChE inhibiting activity. Aqueous chlorination with hypochlorite of these P=S compound solutions was also shown to produce compounds with mutagencity onS. typhimuriumTA98 without S9 mix. The production of mutagens is dependent on the parent pesticides, the solution pH values, and the reaction time.