Impaired corticomuscular coherence during isometric elbow flexion contractions in humans with cervical spinal cord injury
Impaired corticomuscular coherence during isometric elbow flexion contractions in humans with cervical spinal cord injury
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DOI：
10.1111/ejn.13641
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发表时间：
2017-08-01
影响因子：
3.4
通讯作者：
Amarantini, David
中科院分区：
文献类型：
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作者：
Cremoux, Sylvain;Tallet, Jessica;Amarantini, David
脊髓损伤（SCI）后，神经肌肉系统的重组导致拮抗剂肌肉的共激活增加，即在随意收缩时拮抗剂与激动剂肌肉的激活比增加。增加的肌肉共激活被认为是由于减少了皮质对脊髓机制抑制拮抗肌肉的影响。通过对不同力水平脊髓损伤被试皮层和肌肉活动与皮质肌相干性（CMC）残留相互作用的评估，可能为研究肌肉共激活的调控提供新的思路。为了实现这一目标，我们比较了脊髓损伤参与者和健康参与者在三种力水平下进行实际等长肘关节屈曲收缩时，激动剂和拮抗剂肌肉的净关节扭矩、肌肉共激活和相似于10和相似于20Hz的CMC。对于所有参与者来说，随着关节净扭矩的增加，整体CMC和肌肉共同激活都有所下降，但只有类似于10Hz的CMC与肌肉共同激活相关。在最高的力水平下，脊髓损伤的参与者有更大的肌肉共激活和更低的CMC（类似于10Hz）。这些结果强调了CMC作为一种机制的重要性，它可以参与肌肉协同激活的调节，以维持特定的力水平。在脊髓损伤参与者中，类似于10Hz的较低CMC可能反映了皮质对脊柱机制的影响减少，导致肌肉共激活增加，尽管脊髓损伤后皮质-肌肉耦合的可塑性似乎保留了以调节力水平。在临床上，CMC可以有效地评估脊髓损伤后神经肌肉系统的残余完整性和康复效果。
After spinal cord injury (SCI), the reorganization of the neuromuscular system leads to increased antagonist muscles' co-activationthat is, increased antagonist vs. agonist muscles activation ratioduring voluntary contractions. Increased muscle co-activation is supposed to result from reduced cortical influences on spinal mechanisms inhibiting antagonist muscles. The assessment of the residual interactions between cortical and muscles activity with corticomuscular coherence (CMC) in participants with SCI producing different force levels may shed new lights on the regulation of muscle co-activation. To achieve this aim, we compared the net joint torque, the muscle co-activation and the CMC similar to 10 and similar to 20Hz with both agonist and antagonist muscles in participants with SCI and healthy participants performing actual isometric elbow flexion contractions at three force levels. For all participants, overall CMC and muscle co-activation decreased with the increase in the net joint torque, but only CMC similar to 10Hz was correlated with muscle co-activation. Participants with SCI had greater muscle co-activation and lower CMC similar to 10Hz, at the highest force levels. These results emphasize the importance of CMC as a mechanism that could take part in the modulation of muscle co-activation to maintain a specific force level. Lower CMC similar to 10Hz in SCI participants may reflect the decreased cortical influence on spinal mechanisms, leading to increased muscle co-activation, although plasticity of the corticomuscular coupling seems to be preserved after SCI to modulate the force level. Clinically, the CMC may efficiently evaluate the residual integrity of the neuromuscular system after SCI and the effects of rehabilitation.