Prevalence of the metabolic syndrome in individuals with hyperuricemia
Prevalence of the metabolic syndrome in individuals with hyperuricemia
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DOI：
10.1016/j.amjmed.2006.06.040
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发表时间：
2007-05-01
影响因子：
5.9
通讯作者：
Ford, Earl S.
中科院分区：
文献类型：
--
作者：
Choi, Hyon K.;Ford, Earl S.
目得：高尿酸血症和胰岛素抵抗之间的联系已被注意到，但代谢综合征的患病率与高尿酸血症的个人最近的定义仍然不清楚。我们的目的是确定代谢综合征的患病率根据血清尿酸水平在全国代表性的样本美国adultes.METHODS：通过使用数据从8669名参与者年龄在20岁以上的第三次全国健康与营养检查调查（1988- 1994年），我们确定了代谢综合征的患病率在不同的血清尿酸水平。我们使用了修订后的和原始的国家胆固醇教育计划成人治疗小组（NCEP/ ATP）III标准来定义代谢综合征。根据修订的NCEP/ ATP III标准，代谢综合征的患病率为18.9%（95%置信区间[ CI]，16.8- 21.0）尿酸水平低于6 mg/ dL，36.0%（95% CI，32.5- 39.6）尿酸水平为6 - 6.9 mg/ dL，40.8%（95% CI，35.3- 46.4）尿酸水平为7 - 7.9 mg/ dL，59.7%（95% CI，53.0- 66.4），尿酸水平9 - 9.9 mg/ dL为62.0%（95% CI，53.0- 66.4），尿酸水平10 mg/ dL或更高为70.7%。在按性别、年龄组、酒精摄入量、体重指数、高血压和糖尿病分层的亚组中，这种增加的趋势持续存在。例如，在体重指数正常（< 25 kg/m2）的个体中，尿酸水平低于6 mg/ dL的患病率为5.9%（95% CI，4.8- 7.0），尿酸水平高于10 mg/dL的患病率为59.0%（95% CI，20.1- 97.9）。与原来的NCEP/ ATP标准，相应的患病率略lower.CONCLUSIONS：这些研究结果从一个全国代表性的美国成年人样本表明，代谢综合征的患病率大幅增加，血清尿酸水平的增加。医师应认识到代谢综合征是高尿酸血症的常见合并症，并对其进行治疗以预防严重并发症。(c)2007年爱思唯尔公司All rights reserved.
PURPOSE: The link between hyperuricemia and insulin resistance has been noted, but the prevalence of the metabolic syndrome by recent definitions among individuals with hyperuricemia remains unclear. Our objective was to determine the prevalence of the metabolic syndrome according to serum uric acid levels in a nationally representative sample of US adults.METHODS: By using data from 8669 participants aged 20 years and more in The Third National Health and Nutrition Examination Survey ( 1988- 1994), we determined the prevalence of the metabolic syndrome at different serum uric acid levels. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel ( NCEP/ ATP) III criteria to define the metabolic syndrome.RESULTS: The prevalences of the metabolic syndrome according to the revised NCEP/ ATP III criteria were 18.9% ( 95% confidence interval [ CI], 16.8- 21.0) for uric acid levels less than 6 mg/ dL, 36.0% ( 95% CI, 32.5- 39.6) for uric acid levels from 6 to 6.9 mg/ dL, 40.8% ( 95% CI, 35.3- 46.4) for uric acid levels from 7 to 7.9 mg/ dL, 59.7% ( 95% CI, 53.0- 66.4) for uric acid levels from 8 to 8.9 mg/ dL, 62.0% ( 95% CI, 53.0- 66.4) for uric acid levels from 9 to 9.9 mg/ dL, and 70.7% for uric acid levels of 10 mg/ dL or greater. The increasing trends persisted in subgroups stratified by sex, age group, alcohol intake, body mass index, hypertension, and diabetes. For example, among individuals with normal body mass index ( < 25 kg/ m(2)), the prevalence increased from 5.9% ( 95% CI, 4.8- 7.0), for a uric acid level of less than 6 mg/ dL, to 59.0%, ( 95% CI, 20.1- 97.9) for a uric acid level of 10 mg/ dL or greater. With the original NCEP/ ATP criteria, the corresponding prevalences were slightly lower.CONCLUSIONS: These findings from a nationally representative sample of US adults indicate that the prevalence of the metabolic syndrome increases substantially with increasing levels of serum uric acid. Physicians should recognize the metabolic syndrome as a frequent comorbidity of hyperuricemia and treat it to prevent serious complications. (c) 2007 Elsevier Inc. All rights reserved.