Response properties of local field potentials and neighboring single neurons in awake primary visual cortex.
Response properties of local field potentials and neighboring single neurons in awake primary visual cortex.
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DOI：
10.1523/jneurosci.0429-12.2012
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发表时间：
2012-08-15
期刊：
影响因子：
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通讯作者：
Alonso JM
中科院分区：
文献类型：
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作者：
Lashgari R;Li X;Chen Y;Kremkow J;Bereshpolova Y;Swadlow HA;Alonso JM
局部场电位（LFP）的记录在研究和临床应用中越来越普遍，然而，我们对LFP刺激选择性是如何从单个神经元的联合活动中产生的仍然知之甚少。在此，我们系统地比较了清醒灵长类动物V1区LFP和相邻的单单位活性（SUA）的刺激选择性。我们证明了LFP和SUA在取向、运动方向、对比度、大小、时间频率甚至空间相位方面具有相似的刺激偏好。然而，平均SUA的信噪比比LFP高50倍，对比灵敏度高20%，方向选择性高45%，调谐深度比LFP高15%。低LFP频率（< 30 Hz）与位于皮层电流汇（负LFP）附近具有非线性空间求和和取向/方向选择性差的神经元的峰值频率相关性最强。相比之下，LFP伽马频率（bb0 - 30 Hz）与位于皮质源附近的更多样化的神经元组（LFP阳性）相关。总之，我们的研究结果表明，低频和高频LFP汇集了来自V1神经元的信号，这些神经元具有相似的刺激偏好，但反应特性和皮层深度不同。
Recordings from local field potentials (LFPs) are becoming increasingly common in research and clinical applications, however, we still have a poor understanding of how LFP stimulus selectivity originates from the combined activity of single neurons. Here, we systematically compared the stimulus selectivity of LFP and neighboring single unit activity (SUA) recorded in area V1 of awake primates. We demonstrate that LFP and SUA have similar stimulus preferences for orientation, direction of motion, contrast, size, temporal frequency and even spatial phase. However, the average SUA had 50 times better signal to noise, 20% higher contrast sensitivity, 45% higher direction selectivity and 15% more tuning depth than the average LFP. Low LFP frequencies (< 30 Hz) were most strongly correlated with the spiking frequencies of neurons with non-linear spatial summation and poor orientation/direction selectivity that were located near cortical current sinks (negative LFPs). In contrast, LFP gamma frequencies (> 30 Hz) were correlated with a more diverse group of neurons located near cortical sources (positive LFPs). In summary, our results indicate that low- and high-frequency LFP pools signals from V1 neurons with similar stimulus preferences but different response properties and cortical depths.