Higher Aluminum Concentration in Alzheimer's Disease After Box-Cox Data Transformation
Higher Aluminum Concentration in Alzheimer's Disease After Box-Cox Data Transformation
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DOI：
10.1007/s12640-011-9246-y
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发表时间：
2011-11-01
影响因子：
3.7
通讯作者：
Urban, Pavel
中科院分区：
文献类型：
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作者：
Rusina, Robert;Matej, Radoslav;Urban, Pavel
关于汞和铝在阿尔茨海默病 (AD) 发病机制中的作用的证据仍然存在争议。我们项目的目的是研究脑组织样本中所选金属的含量，并使用特定的数学变换来消除原始数据分布中强烈正偏的缺点。在这项研究中，我们使用原子吸收分光光度法测定了 29 名经神经病理学证实的 AD 患者和 27 名年龄匹配的对照者的海马体和联想视觉皮层中的汞和铝浓度。 Box-Cox 数据转换用于统计评估。数据转换后，AD 大脑的海马平均铝浓度高于对照组（0.357 vs. 0.090 mu g/g；P = 0.039）。汞的结果并不显着。有关微量元素浓度的原始数据存在严重偏差，并且总体上未通过正态性检验。 Box-Cox 变换可以消除这个缺点并允许参数测试。
Evidence regarding the role of mercury and aluminum in the pathogenesis of Alzheimer's disease (AD) remains controversial. The aims of our project were to investigate the content of the selected metals in brain tissue samples and the use of a specific mathematical transform to eliminate the disadvantage of a strong positive skew in the original data distribution. In this study, we used atomic absorption spectrophotometry to determine mercury and aluminum concentrations in the hippocampus and associative visual cortex of 29 neuropathologically confirmed AD and 27 age-matched controls. The Box-Cox data transformation was used for statistical evaluation. AD brains had higher mean aluminum concentrations in the hippocampus than controls (0.357 vs. 0.090 mu g/g; P = 0.039) after data transformation. Results for mercury were not significant. Original data regarding microelement concentrations are heavily skewed and do not pass the normality test in general. A Box-Cox transformation can eliminate this disadvantage and allow parametric testing.