Are we ready for a prospective study to investigate the role of chylomicrons in cardiovascular disease?
Are we ready for a prospective study to investigate the role of chylomicrons in cardiovascular disease?
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DOI：
10.1016/j.atherosclerosissup.2008.05.003
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发表时间：
2008-09-01
影响因子：
--
通讯作者：
Cohn, Jeffrey S.
中科院分区：
文献类型：
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作者：
Cohn, Jeffrey S.
肠道乳糜微粒及其残留物被认为直接或间接地促进动脉粥样硬化的发生和发展。然而，测量餐后高脂血症或apoB-48（乳糜微粒的主要结构蛋白）的血浆浓度不是标准的临床实践。原因是标准化的脂肪耐量试验尚未建立，年龄和性别特异性的正常范围尚未确定。也缺乏适当的成本效益分析。尽管这种分析依赖于可靠的前瞻性数据，这些数据表明在确定的口服脂肪负荷后测量的血浆参数可以比现有的脂质和非脂质危险因素更好地预测心血管疾病（CVD）的存在。除了具有预后价值之外。将血浆乳糜微粒水平与心血管疾病联系起来的积极的前瞻性数据将具有治疗重要性，并将再次强调限制个人膳食的大小、频率和脂肪含量的建议。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Intestinal chylomicrons a rid their remnants are believed to contribute both directly and indirectly to the onset and development of atherosclerosis. Measurement of postprandial triglyceridemia or the plasma concentration of apoB-48 (the principle structural protein of chylomicrons) is not however standard clinical practice. The reason is that a standardized fat tolerance test has riot been established, and age- and gender-specific normal ranges have not been determined. Appropriate cost-benefit analysis is also lacking. although such analysis depends upon reliable prospective data demonstrating that plasma parameters Measured after a defined oral fat load can predict the presence of cardiovascular disease (CVD) better than existing lipid and non-lipid risk factors. In addition to being prognostic value. positive prospective data linking plasma chylomicron levels and CVD would be of therapeutic importance and Would reemphasize advice to restrict the size, frequency and fat content of individual meals. (C) 2008 Elsevier Ireland Ltd. All rights reserved.