INTRACELLULAR PARASITISM
INTRACELLULAR PARASITISM
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DOI：
10.1016/0952-7915(88)90049-0
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发表时间：
1988-09-01
影响因子：
7
通讯作者：
HORWITZ, MA
中科院分区：
文献类型：
--
作者：
HORWITZ, MA
细胞内寄生虫是一组在系统发育上不同的微生物，它们都具有在宿主细胞内入侵和繁殖的能力。一大群突出的细胞内寄生虫利用人单核吞噬细胞作为宿主细胞，本文将仅限于这一组。这一群体中的寄生虫是全世界人类发病和死亡的主要原因。例如，麻风病的病原体分枝杆菌@WE感染了大约1200万人，美国锥虫病或恰加斯病的病原体克氏锥虫在全世界感染了大约800万人。每年，结核分枝杆菌导致约1000万新的结核病病例和约300万人死亡。其他由细胞内寄生虫引起的主要疾病包括皮肤和内脏利什曼病、弓形虫病、军团病、李斯特氏菌病、沙门氏菌病、图拉热病、布鲁氏菌病、鹦鹉热病和组织胞浆菌病。目前的研究旨在通过加强我们对单核吞噬细胞-寄生虫相互作用的基本方面的了解，最终改善这种情况。本审查将侧重于此类研究产生的部分观察结果。
Intracellular parasites are a phylogenetically diverse group of microorganisms that share a capacity to invade and multiply within a host cell. A large and prominent group of intracellular parasites utilizes the human mononuclear phagocyte as host cell, and this review will confine itself to this group. Parasites in this group are major causes of human morbidity and mortality worldwide. For example, Mycobacterium@ we, the causative agent of leprosy, infects approximately 12 million people, and Trypanosoma cruzi, the agent of American trypanosomiasis or Chagas’ disease, infects approximately 8 million worldwide. Each year, Mycobacterium tuberculosis causes approximately 10 million new cases of tuberculosis and approximately 3 million deaths. Other major diseases caused by intracellular parasites include cutaneous and visceral leishmaniasis, toxoplasmosis, legionnaires’ disease, listeriosis, salmonellosis, tularemia, brucellosis, psittacosis, and histoplasmosis.For most diseases caused by intracellular parasites, prevention and therapy are inadequate. Current research is aimed at ultimately improving this situation by enhancing our understanding of fundamental aspects of mononuclear phagocyte-parasite interaction. This review will focus on selected observations arising out of such research.