Gut hormones and the regulation of energy homeostasis
Gut hormones and the regulation of energy homeostasis
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DOI：
10.1038/nature05484
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发表时间：
2006-12-14
期刊：
影响因子：
64.8
通讯作者：
Bloom, Stephen R.
中科院分区：
文献类型：
--
作者：
Murphy, Kevin G.;Bloom, Stephen R.
食物摄入、能量消耗和身体肥胖受到稳态调节。中枢和外周信号将有关当前能量平衡状态的信息传递给关键的大脑区域，包括下丘脑和脑干。饥饿和饱腹感代表了对这些信号的协调反应，其中包括来自肠道的神经和激素信息。近年来，我们对神经和激素脑-肠信号如何调节能量稳态的理解有了很大的进展。肠道激素具有多种生理功能，包括专门针对大脑调节食欲。新的研究表明，肠道激素可用于专门调节人类的能量稳态，并为抗肥胖药物提供靶点。
Food intake, energy expenditure and body adiposity are homeostatically regulated. Central and peripheral signals communicate information about the current state of energy balance to key brain regions, including the hypothalamus and brainstem. Hunger and satiety represent coordinated responses to these signals, which include neural and hormonal messages from the gut. In recent years our understanding of how neural and hormonal brain - gut signalling regulates energy homeostasis has advanced considerably. Gut hormones have various physiological functions that include specifically targeting the brain to regulate appetite. New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs.