BIOMECHANICAL CHANGES IN CONNECTIVE TISSUES INDUCED BY EXPERIMENTAL DIABETES
BIOMECHANICAL CHANGES IN CONNECTIVE TISSUES INDUCED BY EXPERIMENTAL DIABETES
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DOI：
10.1530/acta.0.0980432
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
OXLUND, H
中科院分区：
文献类型：
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作者：
ANDREASSEN, TT;SEYERHANSEN, K;OXLUND, H
本文研究了实验性糖尿病大鼠皮肤和主动脉的生物力学特性。糖尿病30天后，皮肤的胶原蛋白含量减少了30%。通过生物力学测试，糖尿病大鼠的胶原蛋白表现出增加的刚度和强度：最大刚度增加了20%，最大应力下的应变降低了10%。胰岛素治疗阻止了所有变化。糖尿病大鼠和正常大鼠主动脉标本之间无差异。
The biomechanical properties of skin and aorta were studied in rats with experimental (streptozotocin) diabetes. After 30 days of diabetes the collagen content of the skin was diminished by 30%. By biomechanical testing collagen from diabetic rats exhibited increased stiffness and strength: maximal stiffness was increased by 20% and the strain at maximum stress was decreased by 10%. Insulin treatment prevented all changes. No differences were found between aortic specimens from diabetic and normal rats.