Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in vitro fertilization outcome
Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in vitro fertilization outcome
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超过 3,000 名卵巢反应不良患者的累积活产率：对最终体外受精结果的 15 年调查
DOI：
10.1016/j.fertnstert.2018.02.001
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发表时间：
2018-06-01
影响因子：
6.7
通讯作者：
Jin, Lei
中科院分区：
文献类型：
--
作者：
Xu, Bei;Chen, Yingjia;Jin, Lei
目的：估计根据博洛尼亚标准诊断的卵巢反应不良（POR）女性的累积活产率（CLBR）。设计：一项为期15年的基于人群的观察性队列研究。地点：教学医院。患者：在2002年至2016年期间，共有3，391名患有POR的女性从她们的第一个新鲜的非供体IVF周期开始接受随访，直到她们活产或停止治疗。所有IVF和卵胞浆内单精子注射（ICSO）周期和mocycles都包括在内。干预措施：无。主要结局指标：每个启动周期的活产率，多个IVF周期的保守和乐观CLBR。结果：6个IVF周期后的CLBR保守估计为14.9%，乐观估计为35.3%。在保守分析中，43岁女性的CLBR从22%下降。与38岁的女性相比，38岁开始的CLBR显著降低）的CLBR显著低于年轻的不良反应者（43岁）。自然周期IVF对这些患者没有好处。(C)2018年，美国生殖医学会（American Society for Reproductive Medicine）
Objective: To estimate the cumulative live birth rates (CLBRs) in women with poor ovarian response (POR) diagnosed according to the Bologna criteria.Design: A 15-year population-based observational cohort study.Setting: Teaching hospital.Patient(s): Between 2002 and 2016 a total of 3,391 women with POR were followed from their first fresh, nondonor IVF cycle until they had a live birth or discontinued treatment. All IVF and intracytoplasmic sperm injection (ICSO cycles and mocycles were included.Intervention(s): None.Main Outcome Measure(s): Live birth rates per initiated cycle, the conservative and optimistic CLBR for multiple IVF cycles.Result(s): The CLBRs after six IVF cycles were 14.9% for the conservative and 35.3% for the optimistic estimate. The CLBR decreased from 22% for women 43 years in the conservative analysis. There was a significant decreased CLBR starting at age 38 years compared with women = 38 years) achieved a significantly lower CLBR than young poor responders (43 years old. Natural cycle IVF is of no benefit for these patients. (C) 2018 by American Society for Reproductive Medicine.