Relationships between the Fear of COVID-19 Scale and regional brain atrophy in mild cognitive impairment
Relationships between the Fear of COVID-19 Scale and regional brain atrophy in mild cognitive impairment
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轻度认知障碍患者对 COVID-19 的恐惧量表与局部脑萎缩的关系
DOI：
10.1017/neu.2022.7
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发表时间：
2022
影响因子：
3.8
通讯作者：
Arai Tetsuaki
中科院分区：
文献类型：
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作者：
Takahashi Takumi;Ota Miho;Numata Yuriko;Kitabatake Ayako;Nemoto Kiyotaka;Tamura Masashi;Ide Masayuki;Matsuzaki Asaki;Kaneda Yuko;Arai Tetsuaki
背景多项研究报告称，2019年冠状病毒病（COVID-19）大流行影响了老年人的认知功能。然而，尚未评估COVID-19相关恐惧对脑萎缩的影响。在这项研究中，我们通过使用磁共振成像（MRI）分析脑体积随时间的变化来评估脑萎缩与COVID-19相关恐惧的影响之间的关系。方法参与者是25名患有轻度认知障碍（MCI）或主观认知下降（SCD）的日本患者，他们接受了两次1.5特斯拉的MRI扫描，一次在COVID-19大流行爆发之前，一次在COVID-19大流行爆发之后，以及在此期间对冠状病毒疾病的恐惧2019量表（FCV-19 S）的评估。我们计算区域性脑萎缩，每天之间的第一次和第二次扫描，并评估之间的关系FCV-19 S评分和区域shrinkage.ResultsThere总FCV-19 S评分和体积减少每天在右后扣带回皮质之间有显着的正相关性。关于FCV-19 S的分量表，我们发现FCV-19 S的因子2和右后扣带回cortex.ConclusionsThere的收缩率之间存在显着的正相关性FCV-19 S评分和区域性脑萎缩每天。尽管已经知道COVID-19大流行的心理影响会导致认知功能下降，但我们的研究结果进一步表明，与COVID-19相关的焦虑和恐惧会导致局部脑萎缩。
BackgroundSeveral studies have reported that the pandemic of coronavirus disease 2019 (COVID-19) influenced cognitive function in the elderly. However, the effect of COVID-19-related fear on brain atrophy has not been evaluated. In this study, we evaluated the relation between brain atrophy and the effect of COVID-19-related fear by analysing changes in brain volume over time using magnetic resonance imaging (MRI).MethodsParticipants were 25 Japanese patients with mild cognitive impairment (MCI) or subjective cognitive decline (SCD), who underwent 1.5-tesla MRI scan twice, once before and once after the pandemic outbreak of COVID-19, and the Fear of Coronavirus Disease 2019 Scale (FCV-19S) assessment during that period. We computed regional brain atrophy per day between the 1st and 2nd scan, and evaluated the relation between the FCV-19S scores and regional shrinkage.ResultsThere was significant positive correlation between the total FCV-19S score and volume reduction per day in the right posterior cingulate cortex. Regarding the subscales of FCV-19S, we found significant positive correlation between factor 2 of the FCV-19S and shrinkage of the right posterior cingulate cortex.ConclusionsThere was positive correlation between the FCV-19S score and regional brain atrophy per day. Although it is already known that the psychological effects surrounding the COVID-19 pandemic cause cognitive function decline, our results further suggest that anxiety and fear related to COVID-19 cause regional brain atrophy.