Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species.
Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species.
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群体基因组学揭示了挪威棕色大鼠与其兄弟物种之间的物种形成和基因渗入
DOI：
10.1093/molbev/msx157
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发表时间：
2017-09-01
影响因子：
10.7
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Teng H;Zhang Y;Shi C;Mao F;Cai W;Lu L;Zhao F;Sun Z;Zhang J
鼠类啮齿类动物是研究适应性辐射和物种形成的优秀模型。褐挪威鼠（褐家鼠）是成功的全球殖民者，其驯化的实验室菌株对生物医学研究的贡献是公认的。为了确定大鼠基于核苷酸的物种形成时间和有助于其定植能力的基因组信息，我们分析了野生褐挪威大鼠及其兄弟物种褐褐大鼠的51个全基因组序列，并在野生褐挪威大鼠中发现了超过2000万个实验室菌株中没有的遗传变异，这大大扩展了大鼠遗传多样性的储存库。我们发现，大鼠及其兄弟的分化与中更新世期间发生的剧烈气候变化相吻合。此外，我们发现在褐挪威大鼠和兄弟物种之间存在地理上广泛的基因流入，导致混合褐挪威大鼠的基因组中存在许多渗入区域。有趣的是，与这些渗入区域之间的化学通讯相关的基因似乎有助于混合褐挪威鼠的种群特异性适应。我们的数据揭示了褐挪威鼠的进化史，并为气候变化在动物物种形成中的作用以及物种间渗入对动物适应的影响提供了新的见解。
Murine rodents are excellent models for study of adaptive radiations and speciation. Brown Norway rats (Rattus norvegicus) are successful global colonizers and the contributions of their domesticated laboratory strains to biomedical research are well established. To identify nucleotide-based speciation timing of the rat and genomic information contributing to its colonization capabilities, we analyzed 51 whole-genome sequences of wild-derived Brown Norway rats and their sibling species, R. nitidus, and identified over 20 million genetic variants in the wild Brown Norway rats that were absent in the laboratory strains, which substantially expand the reservoir of rat genetic diversity. We showed that divergence of the rat and its siblings coincided with drastic climatic changes that occurred during the Middle Pleistocene. Further, we revealed that there was a geographically widespread influx of genes between Brown Norway rats and the sibling species following the divergence, resulting in numerous introgressed regions in the genomes of admixed Brown Norway rats. Intriguing, genes related to chemical communications among these introgressed regions appeared to contribute to the population-specific adaptations of the admixed Brown Norway rats. Our data reveals evolutionary history of the Brown Norway rat, and offers new insights into the role of climatic changes in speciation of animals and the effect of interspecies introgression on animal adaptation.
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影响因子：
1.1
作者：
Chingangbam, Dhananjoy S.;Laishram, Joykumar M.;Suzuki, Hitoshi
通讯作者：
Suzuki, Hitoshi
影响因子：
7
作者：
Chen, Hua;Patterson, Nick;Reich, David
通讯作者：
Reich, David
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
30.8
作者：
通讯作者：
--
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
褐家鼠最近的进化是由有效种群规模的下降造成的。
影响因子：
10.7
作者：
Deinum EE;Halligan DL;Ness RW;Zhang YH;Cong L;Zhang JX;Keightley PD
通讯作者：
Keightley PD