Anaplastic Carcinoma of the Thyroid in a Patient Receiving Radio-Iodine Therapy for Amiodarone-Induced Thyrotoxicosis
Anaplastic Carcinoma of the Thyroid in a Patient Receiving Radio-Iodine Therapy for Amiodarone-Induced Thyrotoxicosis
复制标题
因胺碘酮引起的甲状腺毒症而接受放射碘治疗的甲状腺未变性癌患者
作者：
A. Bridges;R. Davies;R. Newton;G. Mcneill
我们描述了一个案件胺碘酮诱导甲状腺毒症后，心脏瓣膜置换术的患者与多结节甲状腺肿。他对卡比马唑和高氯酸钾的药物治疗有反应。放射性碘治疗30周后发生甲状腺未分化癌。胺碘酮可能导致甲状腺对放射性碘的低摄取。目前尚不清楚这种可能的低剂量电离辐射暴露是否在未分化癌的发展中发挥了作用。
We describe a case of amiodarone-induced thyrotoxicosis following heart valve replacement in a patient with a multinodular goitre. He responded to medical therapy with carbimazole and potassium perchlorate. Subsequent therapy with radio-iodine was followed 30 weeks later by the development of anaplastic thyroid carcinoma. It is possible that amiodarone caused a low uptake of radio-iodine by the thyroid. It is not known whether this possible low dose exposure to ionising radiation played a part in the development of the anaplastic carcinoma.