Simultaneous acceleration of osteogenesis and angiogenesis by surface oxygen vacancies of rutile nanorods
Simultaneous acceleration of osteogenesis and angiogenesis by surface oxygen vacancies of rutile nanorods
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金红石纳米棒表面氧空位同时加速成骨和血管生成
DOI：
10.1016/j.colsurfb.2022.112348
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发表时间：
2022-01-25
影响因子：
5.8
通讯作者：
Chen, Qianming
中科院分区：
文献类型：
--
作者：
Huang, Liyuan;Shen, Jie;Chen, Qianming
同时具有加速成骨和血管生成能力的先进植入物对于骨整合非常重要。通过生物活性分子或离子修饰生物材料表面以促进骨生成和血管生成的研究受到了广泛的关注，但人们往往忽略了材料表面原子尺度的内在物理机制。在这项研究中，我们证明，金红石纳米棒的表面氧空位缺陷的调节能够同时加速骨生成和血管生成。金红石纳米棒表面氧空位缺陷的浓度可以通过简单的氧化还原处理来控制。在富氧表面上，间充质干细胞（MSCs）的成骨分化、人脐静脉内皮细胞（HUVECs）的血管生成分化和血管样管状结构均显著上调。因此，这项工作强调了材料固有的原子尺度特征的关键作用，并提供了一种新的策略，以加速钛基植入物的成骨和血管生成。
Advanced implants with simultaneous accelerated osteogenic and angiogenic capacities are of great importance for osteointegration. Much attention has been paid to simultaneously enhancing the osteogenesis and angiogenesis by surface decoration of bioactive molecules or ions on biomaterial surface, but the inherent physical cue of material surface down to the atomic-scale features have always been ignored. In this study, we demonstrate that regulation of surface oxygen vacancies defects of rutile nanorods are able to simultaneous accelerate the osteogenesis and angiogenesis. The concentration of surface oxygen vacancies defects of rutile nanorods can be manipulated by simple redox processing. The osteogenic differentiation of mesenchymal stem cells (MSCs), angiogenic differentiation and vessel-like tube structures of human umbilical vein endothelial cells (HUVECs) on oxygen vacancies rich surface are significantly up-regulated. This work therefore emphasizes the critical role of the inherent material atomic-scale features and provides a novel strategy to accelerate the osteogenesis and angiogenesis of Ti-based implant.