Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis.
Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis.
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胶质母细胞瘤与外侧心室的接触对生存的影响：一项荟萃分析。
DOI：
10.1007/s11060-016-2278-7
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发表时间：
2017-01
影响因子：
3.9
通讯作者：
Ihrie RA
中科院分区：
文献类型：
--
作者：
Mistry AM;Hale AT;Chambless LB;Weaver KD;Thompson RC;Ihrie RA
脑室-脑室下区（V-SVZ）位于侧脑室（LV）壁，是成人脑内最大的神经源性小生境。影像学检查是否与左心室接触影响胶质母细胞瘤（GBM）患者的生存率仍不清楚。我们吸收并分析了比较（LV+GBM）和无（LV−GBM）放射学LV接触的GBM患者生存率的已发表数据。检索PubMed、EMBASE和科克伦电子数据库。确定了15项具有LV+GBM和LV−GBM患者生存数据的研究。将其Kaplan-Meier生存曲线数字化并汇总，以生成中位总体（OS）和无进展（PFS）生存期以及对数秩风险比（HR）。通过荟萃分析分别分析了考虑GBM生存的常见预测因素后的对数秩和报告的多变量HR。根据汇总数据计算的LV+ GBM和LV− GBM的中位生存期（月）分别为12.95和16.58（OS）以及4.54和6.25（PFS），总体对数秩HR为1.335 [1.204-1.513]（OS）和1.387 [1.225-1.602]（PFS）。对数秩HR的荟萃分析得出的汇总HR为1.58 [1.35-1.85]（OS，10项研究）和1.41 [1.22-1.64]（PFS，5项研究）。多变量HR的荟萃分析得出的汇总HR为1.35 [1.14-1.58]（OS，6项研究）和1.64 [0.88-3.05]（PFS，3项研究）。GBM接触LV的患者生存率较低。这种效应可能独立于GBM生存的常见预测因子，表明V-SVZ接触对GBM生物学的临床影响。
The ventricular-subventricular zone (V-SVZ), which lies in the walls of the lateral ventricles (LV), is the largest neurogenic niche within the adult brain. Whether radiographic contact with the LV influences survival in glioblastoma (GBM) patients remains unclear. We assimilated and analyzed published data comparing survival in GBM patients with (LV+GBM) and without (LV−GBM) radiographic LV contact. PubMed, EMBASE, and Cochrane electronic databases were searched. Fifteen studies with survival data on LV+GBM and LV−GBM patients were identified. Their Kaplan–Meier survival curves were digitized and pooled for generation of median overall (OS) and progression free (PFS) survivals and log-rank hazard ratios (HRs). The log-rank and reported multivariate HRs after accounting for the common predictors of GBM survival were analyzed separately by meta-analyses. The calculated median survivals (months) from pooled data were 12.95 and 16.58 (OS), and 4.54 and 6.25 (PFS) for LV+GBMs and LV−GBMs, respectively, with an overall log-rank HRs of 1.335 [1.204–1.513] (OS) and 1.387 [1.225–1.602] (PFS). Meta-analysis of log-rank HRs resulted in summary HRs of 1.58 [1.35–1.85] (OS, 10 studies) and 1.41 [1.22–1.64] (PFS, 5 studies). Meta-analysis of multivariate HRs resulted in summary HRs of 1.35 [1.14–1.58] (OS, 6 studies) and 1.64 [0.88–3.05] (PFS, 3 studies). Patients with GBM contacting the LV have lower survival. This effect may be independent of the common predictors of GBM survival, suggesting a clinical influence of V-SVZ contact on GBM biology.