Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
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DOI：
10.1038/bjc.1993.423
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发表时间：
1993-10
影响因子：
8.8
通讯作者：
Koshiba, K
中科院分区：
文献类型：
--
作者：
Uchida, T;Wada, C;Shitara, T;Egawa, S;Koshiba, K
研究了日本男性前列腺癌或良性前列腺增生患者中p53突变的发生率。采用聚合酶链反应-单链构象多态性（PCR-SSCP）作为初筛技术，对阳性病例进行基因测序。21例前列腺癌中有2例（9.5%）发现有p53突变。这些是B2和D2期前列腺癌。其余病例未发现异常或良性前列腺增生。因此，p53基因突变在原发性前列腺癌的肿瘤发生中并不常见。
A study was made of the incidence of p53 mutations in Japanese males with prostate cancer or benign prostatic hyperplasia. Polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) was used as a primary screening technique with gene sequencing being carried out in positive cases. Two out of 21 prostate cancers (9.5%) were found to have p53 mutations. These were stage B2 and D2 prostate cancers. No abnormalities were found in the remaining cases or benign prostatic hyperplasia. Mutations of the p53 gene would thus appear infrequent in the tumourigenesis of primary prostate cancer.