EFFECT OF DEOXYCHOLATE, AMPHOTERICIN-B AND FONGIZONE ON TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS
EFFECT OF DEOXYCHOLATE, AMPHOTERICIN-B AND FONGIZONE ON TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS
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DOI：
10.1016/s0769-2617(87)80019-9
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发表时间：
1987-07-01
期刊：
影响因子：
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通讯作者：
AYNAUD, JM
中科院分区：
文献类型：
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作者：
NGUYEN, TD;BOTTREAU, E;AYNAUD, JM
在2 μ g/ml的浓度下，阿替霉素B和脱氧胆酸盐对传染性胃肠炎冠状病毒感染性都没有灭活作用。然而，白喉菌素B刺激琼脂糖中的空斑形成，并促进病毒RNA进入猪睾丸细胞。联合使用阿替霉素B+脱氧胆酸盐灭活病毒感染性，并诱导斑块直径减小。最后，在这些试剂的存在下，感染性病毒和干扰素的产生没有变化。
At a concentration of 2 .mu.g/ml, neither amphotericin B nor deoxycholate had an inactivating effect upon transmissible gastroenteritis coronavirus infectivity. However, amphothericin B stimulated plaque formation in agarose and facilitated the entry of viral RNA into swine testis cells. The combination of amphotericin B+ deoxycholate inactivated virus infectivity and induced a decrease in plaque diameter. Finally, in the presence of these agents, the production of infectious virus and interferon was unchanged.