Alpha-synuclein and tau: teammates in neurodegeneration?
Alpha-synuclein and tau: teammates in neurodegeneration?
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DOI：
10.1186/1750-1326-9-43
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发表时间：
2014-10-29
影响因子：
15.1
通讯作者：
McLean PJ
中科院分区：
文献类型：
--
作者：
Moussaud S;Jones DR;Moussaud-Lamodière EL;Delenclos M;Ross OA;McLean PJ
α-突触核蛋白聚集体的积累是帕金森病的标志，更普遍的是突触核蛋白病。然而，tau聚集体的积累通常在痴呆症患者的大脑中发现，这种类型的神经病理特征明确定义了tau病变。然而，在许多情况下，α-突触核蛋白阳性包涵体也被描述为牛头病变，反之亦然，表明这些蛋白质病变共存或串扰。有趣的是，α-突触核蛋白和tau蛋白具有惊人的共同特征，表明它们可能协同工作。Tau和α-突触核蛋白都是部分未折叠的蛋白，在病理条件下可形成毒性低聚物和异常的细胞内聚集体。此外，这两种基因的突变都会导致严重的显性家族性神经变性。此外，tau蛋白和α-突触核蛋白在体外和体内都能促进彼此的成纤维和溶解性。这表明tau蛋白和α-突触核蛋白之间的相互作用形成了一个有害的前馈循环，这对神经退行性疾病的发展和扩散至关重要。在这里，我们回顾了最近关于阐明α-突触核蛋白和tau之间可能联系的文献。
The accumulation of α-synuclein aggregates is the hallmark of Parkinson’s disease, and more generally of synucleinopathies. The accumulation of tau aggregates however is classically found in the brains of patients with dementia, and this type of neuropathological feature specifically defines the tauopathies. Nevertheless, in numerous cases α-synuclein positive inclusions are also described in tauopathies and vice versa, suggesting a co-existence or crosstalk of these proteinopathies. Interestingly, α-synuclein and tau share striking common characteristics suggesting that they may work in concord. Tau and α-synuclein are both partially unfolded proteins that can form toxic oligomers and abnormal intracellular aggregates under pathological conditions. Furthermore, mutations in either are responsible for severe dominant familial neurodegeneration. Moreover, tau and α-synuclein appear to promote the fibrillization and solubility of each other in vitro and in vivo. This suggests that interactions between tau and α-synuclein form a deleterious feed-forward loop essential for the development and spreading of neurodegeneration. Here, we review the recent literature with respect to elucidating the possible links between α-synuclein and tau.
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影响因子：
8.6
作者：
Appel-Cresswell, Silke;Vilarino-Guell, Carles;Farrer, Matthew J.
通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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