Origin and evolution of the Rax homeobox gene by comprehensive evolutionary analysis
Origin and evolution of the Rax homeobox gene by comprehensive evolutionary analysis
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DOI：
10.1002/2211-5463.12832
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发表时间：
2020-03-19
期刊：
影响因子：
2.6
通讯作者：
Furukawa, Takahisa
中科院分区：
文献类型：
--
作者：
Kon, Tetsuo;Furukawa, Takahisa
Rax是脊椎动物眼睛发育的关键转录因子之一。在这项研究中，我们对Rax进行了全面的进化分析。我们发现两侧门和刺虫门具有Rax基因，而Placozoa、Porifera和Ctenophora没有，这意味着Rax基因的起源可以追溯到刺虫门和两侧门的共同祖先。对有颌和无颌脊椎动物Rax基因座的分子系统发育和同源性分析结果表明，Rax基因座的片段重复发生在有颌脊椎动物的一个早期共同祖先中，导致有颌脊椎动物Rax和Rax2两个Rax类群。通过分析来自所有四大类哺乳动物的86个哺乳动物基因组，我们发现至少有5个独立的Rax2基因丢失事件发生在哺乳动物中。这项研究可能为眼睛的进化提供新的见解。
Rax is one of the key transcription factors crucial for vertebrate eye development. In this study, we conducted comprehensive evolutionary analysis of Rax. We found that Bilateria and Cnidaria possess Rax, but Placozoa, Porifera, and Ctenophora do not, implying that the origin of the Rax gene dates back to the common ancestor of Cnidaria and Bilateria. The results of molecular phylogenetic and synteny analyses on Rax loci between jawed and jawless vertebrates indicate that segmental duplication of the Rax locus occurred in an early common ancestor of jawed vertebrates, resulting in two Rax paralogs in jawed vertebrates, Rax and Rax2. By analyzing 86 mammalian genomes from all four major groups of mammals, we found that at least five independent Rax2 gene loss events occurred in mammals. This study may provide novel insights into the evolution of the eye.