Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy.
Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy.
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长期音乐辅助治疗可增强小剂量抗癫痫药物治疗颞叶癫痫的疗效。
DOI：
10.1111/cns.13623
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发表时间：
2022-03
影响因子：
5.5
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Xu CL;Nao JZ;Shen YJ;Gong YW;Tan B;Zhang S;Shen KX;Sun CR;Wang Y;Chen Z
非侵入性音乐辅助治疗与常规抗癫痫药物联合应用，在改善癫痫控制方面显示出巨大潜力。然而，以前的音乐协议的多样性导致了不同的结果。音乐辅助治疗的优化方案和特点尚不完全清楚，这限制了其可行性。通过在不同的颞叶癫痫模型中应用不同的音乐治疗方案，我们评估了音乐联合亚剂量药物对癫痫发作的影响，以确定最佳方案。对音乐辅助治疗有反应的一组点燃的小鼠进行了筛选。在这些小鼠中，对点燃的癫痫无效的亚剂量药物，在每天12小时的莫扎特K.448连续14天后，减轻了癫痫的严重程度。较短时间的音乐治疗(每天2小时和6小时)无效。此外，只有全长的莫扎特K.448，而不是它的剧集或其他音乐品种，才能增强亚剂量药物的疗效。这种音乐治疗作用不是由于脑内药物浓度的增加，而是与其对海马区癫痫脑电谱功率的调制有关。这些结果表明，长期全长莫扎特K.448可以增强亚剂量药物的抗癫痫疗效，可能是一种有前途的非侵入性辅助治疗颞叶癫痫的方法。音乐辅助治疗可促进亚剂量抗癫痫药物在海马和杏仁核点燃的颞叶癫痫小鼠中的疗效。每天听12小时的全长莫扎特K.448是音乐辅助治疗的最佳方案。
Noninvasive music adjuvant therapy shows great potential in improving seizure control when combined with routine antiepileptic drugs. However, the diversity of previous music protocols has resulted in disparate outcomes. The optimized protocol and features for music adjuvant therapy are still not fully understood which limits its feasibility. By applying different regimens of music therapy in various temporal lobe epilepsy models, we evaluated the effect of music in combination with sub‐dose drugs on epileptic seizures to determine the optimized protocol. A subgroup of kindled mice that were responsive to music adjuvant therapy was screened. In those mice, sub‐dose drugs which were noneffective on kindled seizures, alleviated seizure severity after 12 h/day Mozart K.448 for 14 days. Shorter durations of music therapy (2 and 6 h/day) were ineffective. Furthermore, only full‐length Mozart K.448, not its episodes or other music varieties, was capable of enhancing the efficacy of sub‐dose drugs. This music therapeutic effect was not due to increasing cerebral drug concentration, but instead was related with the modulation of seizure electroencephalogram (EEG) spectral powers in the hippocampus. These results indicate that long‐term full‐length Mozart K.448 could enhance the anti‐seizure efficacy of sub‐dose drugs and may be a promising noninvasive adjuvant therapy for temporal lobe epilepsy. Music adjuvant therapy promotes the efficacy of sub‐dose antiepileptic drugs in both hippocampal and amygdaloid kindled temporal lobe epileptic mice. Listening to full‐length Mozart K.448 for 12 h/day is the optimal protocol for music adjuvant therapy.
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影响因子：
3
作者：
Grylls, Eliza;Kinsky, Max;McLellan, Ailsa
通讯作者：
McLellan, Ailsa
DOI：
10.1177/155005949802900301
发表时间：
1998-07-01
期刊：
CLINICAL ELECTROENCEPHALOGRAPHY
影响因子：
--
作者：
Hughes, JR;Daaboul, Y;Shaw, GL
通讯作者：
Shaw, GL
影响因子：
2.6
作者：
Lin, Lung-Chang;Lee, Wei-Te;Yang, Rei-Cheng
通讯作者：
Yang, Rei-Cheng
影响因子：
2.6
作者：
Chen, Baibing;Choi, Hyunmi;Detyniecki, Kamil
通讯作者：
Detyniecki, Kamil
罗格列酮极化小胶质细胞并预防毛果芸香碱诱发的癫痫持续状态
影响因子：
5.5
作者：
Peng, Jing;Wang, Kan;Guan, Yangtai
通讯作者：
Guan, Yangtai