Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders.
Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders.
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DOI：
10.12659/msm.889853
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发表时间：
2014-01-24
期刊：
影响因子：
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通讯作者：
Gałecki P
中科院分区：
文献类型：
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作者：
Talarowska M;Bobińska K;Zajączkowska M;Su KP;Maes M;Gałecki P
数据显示，高达38.2%的欧洲人口患有精神障碍，复发性抑郁障碍(RDD)是最常被诊断为致残的疾病之一。在过去的几年里，RDD的神经认知损害已经成为一个新的研究前沿，关注认知功能下降在RDD过程中的作用以及与其临床表现和预后的关系。免疫炎症和氧化亚硝化应激(O&NS)过程在RDD认知功能障碍的发生发展中可能起一定作用。新证据表明，慢性炎症和O&NS反应发生在神经退行性疾病患者和RDD患者的大脑中。这篇叙述性综述介绍了有关选定的炎性和O&NS酶对RDD患者认知功能的可能影响的知识现状。重点介绍了锰超氧化物歧化酶(MnSOD)、诱导型一氧化氮合酶(INOS)和髓过氧化物酶(MPO)。
Data show that up to 38.2% of the European population have a mental disorder and that recurrent depressive disorder (rDD) is among the most commonly diagnosed disabling diseases. Over the last few years, neurocognitive impairments in rDD have become a new research front focusing on the role of cognitive decline during the course of rDD and in relation to its clinical presentation and prognosis. Both immune-inflammatory and oxidative and nitrosative stress (O&NS) processes potentially play a role in development of cognitive dysfunction in rDD. New evidence shows that chronic inflammatory and O&NS reactions occur in the brains of patients with neurodegenerative disorders and those with rDD. This narrative review presents the current state of knowledge on the possible impact of selected inflammatory and O&NS enzymes on cognitive functioning in patients with rDD. We focus on manganese superoxide dismutase (MnSOD), inducible nitric oxide synthase (iNOS), and myeloperoxidase (MPO).