Multidimensional nanomaterials for the control of stem cell fate.
Multidimensional nanomaterials for the control of stem cell fate.
复制标题
用于控制干细胞命运的多维纳米材料。
DOI：
10.1186/s40580-016-0083-9
复制
发表时间：
2016
期刊：
影响因子：
11.7
通讯作者：
Lee KB
中科院分区：
文献类型：
--
作者：
Chueng SD;Yang L;Zhang Y;Lee KB
目前的干细胞治疗在产生分化细胞谱系方面效率较低，分化细胞谱系可以替代原有的受损细胞。另一方面，纳米材料提供独特的物理尺寸、表面化学、电导率和地形微环境，通过多维途径调节干细胞分化，促进基因传递、细胞-细胞和细胞- ecm相互作用。在这篇综述中，纳米材料被证明可以单独或协同指导选择性干细胞分化。从三个不同的纳米技术家族中，展示了三种方法：(1)可溶性微环境因子；(2)不溶性物理微环境；(3)纳米形貌特征。由于再生医学在有效的干细胞治疗方面投入了大量资金，本文的综述受到启发，引发了对多维纳米材料潜在临床应用的讨论。
Current stem cell therapy suffers low efficiency in giving rise to differentiated cell lineages, which can replace the original damaged cells. Nanomaterials, on the other hand, provide unique physical size, surface chemistry, conductivity, and topographical microenvironment to regulate stem cell differentiation through multidimensional approaches to facilitate gene delivery, cell–cell, and cell–ECM interactions. In this review, nanomaterials are demonstrated to work both alone and synergistically to guide selective stem cell differentiation. From three different nanotechnology families, three approaches are shown: (1) soluble microenvironmental factors; (2) insoluble physical microenvironment; and (3) nano-topographical features. As regenerative medicine is heavily invested in effective stem cell therapy, this review is inspired to generate discussions in the potential clinical applications of multi-dimensional nanomaterials.