Effects of nicotine gum dose by level of nicotine dependence.
Effects of nicotine gum dose by level of nicotine dependence.
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尼古丁口香糖剂量对尼古丁依赖程度的影响。
DOI：
10.1080/14622200050011303
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
Vokonas,PS
中科院分区：
文献类型：
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作者：
Garvey,AJ;Kinnunen,T;Nordstrom,BL;Utman,CH;Doherty,K;Rosner,B;Vokonas,PS
我们使用吸烟重度指数（Fagerstrom 尼古丁依赖测试的一个子集）将 608 名计划戒烟的吸烟者分为低尼古丁依赖或高尼古丁依赖。然后，每个依赖程度的受试者被随机分配接受安慰剂、2 毫克或 4 毫克尼古丁口香糖治疗。在一年的随访期间，受试者还接受了简短的（每次访问 5-10 分钟）行为咨询。戒烟后 1 年，接受安慰剂、2 毫克和 4 毫克口香糖的低依赖性吸烟者的戒烟率分别为 11.2%、19.5% 和 18.4%（线性趋势=0.20）。对于高度依赖的吸烟者，安慰剂、2 毫克和 4 毫克口香糖条件下的 1 年戒烟率分别为 6.1%、15.7% 和 20.7%（线性趋势=0.002）。尼古丁口香糖剂量和依赖组之间的相互作用并不显着（p = 0.42），尽管 2 mg 和 4 mg 口香糖均明显比安慰剂口香糖更有效，但 2 mg 和 4 mg 剂量的有效性也没有显着差异。我们还发现尼古丁口香糖对缓解戒烟后心率下降具有显着的剂量相关作用。与戒烟后 1 年戒烟相关的其他变量包括之前尝试戒烟时的戒烟时间较长、已婚、受教育程度较高以及拥有不吸烟的配偶或重要的其他人。结果表明，尼古丁口香糖对戒烟有显着帮助，与安慰剂口香糖使用者相比，成功戒烟的几率增加了一倍多。 4 毫克剂量对高度依赖吸烟者的戒烟率没有显着增加。吸烟史和人口统计变量也对戒烟尝试的结果产生重大影响。
We used the Heaviness of Smoking Index, a subset of the Fagerstrom Test for Nicotine Dependence, to classify 608 cigarette smokers planning a cessation attempt as low or high in nicotine dependence. Subjects within each level of dependence were then randomly assigned to placebo, 2-mg, or 4-mg nicotine gum treatment. Subjects were also provided brief (5–10 min per visit) behavioral counseling during a 1-year period of follow-up. At 1 year post-cessation, quit rates were 11.2, 19.5, and 18.4% for low-dependence smokers receiving placebo, 2-mg, and 4-mg gum, respectively (plinear trend=0.20). For high-dependence smokers, quit rates at 1 year were 6.1, 15.7, and 20.7% for the placebo, 2-mg, and 4-mg gum conditions, respectively (plinear trend=0.002). The interaction of nicotine-gum dose and dependence group was not significant (p=0.42), nor did the 2-mg and 4-mg doses differ significantly in effectiveness, though both 2-mg and 4-mg gum were significantly more effective than placebo gum. We also found a significant dose-related effect for nicotine gum to moderate post-cessation heart-rate decline. Other variables related to abstinence at 1 year post-cessation were a longer period of abstinence on a prior quit attempt, being married, higher education level, and having a non-smoking spouse or significant other. Results indicate that nicotine gum is a significant aid to smoking cessation, more than doubling the odds of successful cessation compared to the odds for placebo-gum users. The 4-mg dose provided a non-significant increase in cessation rates for high-dependence smokers. Smoking history and demographic variables also have a significant impact on the outcome of a quit-smoking attempt.