Angiotensin II type 1 receptor -: Relationship with caveolae and caveolin after initial agonist stimulation
Angiotensin II type 1 receptor -: Relationship with caveolae and caveolin after initial agonist stimulation
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DOI：
10.1161/01.hyp.32.3.459
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发表时间：
1998-09-01
期刊：
影响因子：
8.3
通讯作者：
Alexander, RW
中科院分区：
文献类型：
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作者：
Ishizaka, N;Griendling, KK;Alexander, RW
小窝是与信号转导有关的膜结构域，小窝蛋白是这些结构域的主要结构组分。我们发现，所有报道的小窝蛋白异构体（小窝蛋白-1，2和-3）在血管平滑肌细胞（VSMC）中表达，然而，只有小窝蛋白-1 mRNA的调节血管紧张素II（Ang II）。Ang Ⅱ（100 nmol/L）可增加小窝蛋白-1 mRNA的表达，在2小时达到峰值（对照组的193+/-6%，P
Caveolae are membrane domains that have been implicated in signal transduction, and caveolins are major structural components of these domains. We found that all reported caveolin isoforms (caveolin-1, -2, and -3) were expressed in vascular smooth muscle cells (VSMCs); however, only caveolin-1 mRNA was regulated by angiotensin II (Ang II). Ang II (100 nmol/L) increased caveolin-1 mRNA, with a peak at 2 hours (193+/-6% of control, P