Effect of One-Week Salt Restriction on Blood Pressure Variability in Hypertensive Patients with Type 2 Diabetes.
Effect of One-Week Salt Restriction on Blood Pressure Variability in Hypertensive Patients with Type 2 Diabetes.
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DOI：
10.1371/journal.pone.0144921
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Utsunomiya K
中科院分区：
文献类型：
--
作者：
Iuchi H;Sakamoto M;Suzuki H;Kayama Y;Ohashi K;Hayashi T;Ishizawa S;Yokota T;Tojo K;Yoshimura M;Utsunomiya K
已知 24 小时动态血压监测 (ABPM) 的短期血压 (BP) 变异性增加是心血管事件的危险因素。然而，很少有研究评估限盐对血压变异性的影响，特别是对于患有 2 型糖尿病的高血压患者。本研究旨在探讨限盐对收缩压（SBP）变异性的影响。 10 名患有 2 型糖尿病且未接受抗高血压药物的高血压患者参与了该研究。入院后，所有患者均接受限盐饮食和适当的抗糖尿病治疗，并使用 ABPM 进行连续 7 天的随访。 7 天治疗后，每日 SBP 变异性的中位 [四分位距 (IQR)] 变异系数 (CV) 从第 1 天到第 7 天从 13.0 [10.8 至 16.8] % 变为 13.3 [9.1 至 18.9] % (P = 0.959)，第 1 天和第 7 天之间的中位 [IQR] 变化为 -0.3 [-3.2 至2.9]％。此外，与平均血压值相比，血压变异性的 CV 和血压昼夜节律在 7 天内每天都有很大变化。有趣的是，收缩压变异性的增加与血压昼夜节律的日复一日变化有关。在 10 名未接受抗高血压药物的 2 型糖尿病高血压患者中，7 天住院期间的盐限制导致每日 SBP 变异性 CV 相对于基线发生 -0.3 [-3.2 至 2.9]（中位数 [IQR]）% 变化。 UMIN 临床试验注册中心 UMIN000016243
Increased short-term blood pressure (BP) variability on 24-hour ambulatory BP monitoring (ABPM) is known to be a risk factor for cardiovascular events. However, very few studies have evaluated the effect of salt restriction on BP variability particularly in hypertensive patients with type 2 diabetes. This study aimed to investigate the effect of salt restriction on systolic BP (SBP) variability. 10 hypertensive patients with type 2 diabetes and not receiving antihypertensive agents were enrolled in the study. After admission, all patients received a salt-restricted diet and appropriate anti-diabetic treatments and were followed up for 7 consecutive days using ABPM. After the 7-day treatment, the median [interquartile range (IQR)] coefficient of variation (CV) for diurnal SBP variability changed from day 1 to day 7–13.0 [10.8 to 16.8] % to 13.3 [9.1 to 18.9] % (P = 0.959)—and the median [IQR] change between days 1 and 7 was -0.3 [-3.2 to 2.9] %. In addition, CV for BP variability and circadian rhythm of BP varied greatly on a day-by-day basis for 7 days, compared to mean BP values. Interestingly, increased SBP variability was associated with greater day-by-day changes in circadian rhythm of BP. Salt restriction during 7-day hospitalization led to a -0.3 [-3.2 to 2.9] (median [IQR]) % change from baseline in CV for diurnal SBP variability in 10 hypertensive patients with type 2 diabetes not receiving antihypertensive agents. UMIN Clinical Trials Registry UMIN000016243