Two new alkaloids from Portulaca oleracea and their cytotoxic activities
Two new alkaloids from Portulaca oleracea and their cytotoxic activities
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DOI：
10.1080/10286020.2013.866948
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发表时间：
2014-01
影响因子：
1.7
通讯作者：
Jin-Long Tian;X. Liang;P. Gao;Dan-Qi Li;Qian Sun;Ling-Zhi Li;Shaojiang Song
中科院分区：
文献类型：
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作者：
Jin-Long Tian;X. Liang;P. Gao;Dan-Qi Li;Qian Sun;Ling-Zhi Li;Shaojiang Song
两种新生物碱，名为 (3R)-3,5-双(3-甲氧基-4-羟基苯基)-2,3-二氢-2(1H)-吡啶酮 (1) 和 1,5-二甲基-6-苯基-1,2-二氢-1,2,4-三嗪-3(2H)-一 (2)，以及两种已知化合物 (7'R)-N-阿魏酰去甲肾上腺素 (3) 和N-反式阿魏酰酪胺 (4) 从马齿苋的地上部分中分离出来。通过一维核磁共振、二维核磁共振和 HR-MS 技术等光谱方法阐明了它们的结构和构型。此外，还测试了化合物 1-4 对人肺癌（K562 和 A549）和乳腺癌（MCF-7 和 MDA-MB-435）癌细胞系的体外细胞毒活性。
Two new alkaloids named (3R)-3,5-bis(3-methoxy-4-hydroxyphenyl)-2,3-dihydro-2(1H)-pyridinone (1) and 1,5-dimethyl-6-phenyl-1,2-dihydro-1,2,4-triazin-3(2H)-one (2), together with two known compounds (7′R)-N-feruloyl normetanephrine (3) and N-trans-feruloyl tyramine (4) were isolated from the air-dried aerial parts of Portulaca oleracea L. Their structures and configurations were elucidated by spectroscopic methods including 1D NMR, 2D NMR, and HR-MS techniques. In addition, compounds 1–4 were tested for in vitro cytotoxic activities against human lung (K562 and A549) and breast (MCF-7 and MDA-MB-435) cancer cell lines.