Poly(A)-binding proteins and mRNA localization: who rules the roost?
Poly(A)-binding proteins and mRNA localization: who rules the roost?
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DOI：
10.1042/bst20150171
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发表时间：
2015-12-01
影响因子：
3.9
通讯作者：
Smith, Richard W. P.
中科院分区：
文献类型：
--
作者：
Gray, Nicola K.;Hrabalkova, Lenka;Smith, Richard W. P.
RNA结合蛋白通常是多功能的，与多种蛋白质伴侣相互作用，并在细胞内显示复杂的定位。哺乳动物胞质多聚腺苷酸结合蛋白（PABP）是一种多功能的RNA结合蛋白，可调节mRNA的翻译和稳定性。虽然在稳态下主要是弥漫性的细胞质，但它们穿梭于细胞核，并且可以定位于各种细胞质病灶，包括与mRNA储存和定位翻译相关的那些。有趣的是，PABP亚细胞分布可以响应于细胞应激或病毒感染而显著改变，变为主要是核和/或在诱导的细胞质病灶中富集。然而，相对知之甚少的机制，管理这种分布/重新定位，在许多情况下，PABP功能在特定的网站仍然不清楚。在这里，我们将讨论与这些问题在哺乳动物的新兴证据。
RNA-binding proteins are often multifunctional, interact with a variety of protein partners and display complex localizations within cells. Mammalian cytoplasmic poly(A)-binding proteins (PABPs) are multifunctional RNA-binding proteins that regulate multiple aspects of mRNA translation and stability. Although predominantly diffusely cytoplasmic at steady state, they shuttle through the nucleus and can be localized to a variety of cytoplasmic foci, including those associated with mRNA storage and localized translation. Intriguingly, PABP sub-cellular distribution can alter dramatically in response to cellular stress or viral infection, becoming predominantly nuclear and/or being enriched in induced cytoplasmic foci. However, relatively little is known about the mechanisms that govern this distribution/relocalization and in many cases PABP functions within specific sites remain unclear. Here we discuss the emerging evidence with respect to these questions in mammals.