SHORT-TERM INHIBITION OF CELLULAR AUTOPHAGY BY ISOPROTERENOL IN THE SUBMANDIBULAR-GLAND

SHORT-TERM INHIBITION OF CELLULAR AUTOPHAGY BY ISOPROTERENOL IN THE SUBMANDIBULAR-GLAND
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DOI：
10.1007/bf02890221
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发表时间：
1987-01-01
期刊：
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY
影响因子：
--
通讯作者：
PFEIFER, U
PFEIFER, U
中科院分区：
其他
文献类型：
--
作者：
BAHRO, M;DAMMRICH, J;PFEIFER, U

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本研究考察了异丙肾上腺素对大鼠颌下腺细胞自噬的短期（即注射后 10 分钟）影响。自噬空泡的体积分数显着降低，表明抗分解代谢反应，即细胞自噬的抑制，是下颌下腺生长的早期且重要的事件，已知长期异丙肾上腺素治疗会发生这种情况。
The present study examines the short-term (i.e. 10 min after injection) influence of isoproterenol on cellular autophagy in the rat submandibular gland. The volume fraction of autophagic vacuoles was significantly reduced, suggesting that an anticatabolic reaction, namely inhibition of cellular autophagy, is an early and significant event in the growth of the submandibular gland which is known to occur with long-term isoproterenol treatment.