Anterior temporobasal sulcal morphology: development of a reliable rating protocol and normative data.
Anterior temporobasal sulcal morphology: development of a reliable rating protocol and normative data.
复制标题
前颞基底沟形态：制定可靠的评级方案和规范数据。
DOI：
10.1007/s00429-012-0436-z
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发表时间：
2013
影响因子：
3.1
通讯作者：
Leonard,ChristianaM
中科院分区：
文献类型：
--
作者：
Reckess,GilaZ;Dunn,CallieBeck;Bauer,RussellM;Leonard,ChristianaM
三个前颞基底沟（aTB），即侧副沟、鼻沟和枕颞沟，有助于记忆相关结构的形态，是神经影像学的重要标志。这些脑沟之间相互连接的普遍性可以区分健康成年人和患有记忆相关疾病的个体（Kim 等人 Neurology 70:2159–2165, 2008；Zhan 等人 Hum Brain Mapp 30:874–882, 2009）。然而，量化这种联系的存在和性质的方法是模糊且多种多样的，并且各个研究的规范频率不一致。因此，当前研究的目标有两个：（1）开发一种可靠的方法，根据串行磁共振图像（MRI）生成的表面渲染来识别 aTB 脑沟及其互连。该协议包括培训材料和评级日志（请参阅补充材料），可供其他研究人员传播和应用。 (2) 确定大样本健康成人（200名本科生）中3个aTB脑沟之间相互关联的患病率，可作为今后与临床样本比较的规范数据。值得注意的是，由此产生的协议称为前颞基底沟的脑沟分类评级协议，区分“清晰”和“模糊”连接。当仅包括明确的联系时，我们的患病率与 Ono 等人的尸检结果一致。 (脑沟地图集。Thieme Medical Publishers, Inc.，纽约，1990)；当明确和模糊的连接都被视为连接时，我们的结果在很大程度上复制了基于 MRI 的发现（例如，Kim et al. Neurology 70:2159–2165, 2008）。我们认为，模糊连接的评分者分类的系统变化可以解释文献中的差异。
The three anterior temporobasal (aTB) sulci, which are the collateral, rhinal, and occipitotemporal sulci, contribute to the morphology of memory-related structures and are important landmarks for neuroimaging. Prevalence of inter-connections among these sulci may distinguish healthy adults and individuals with memory-related disorders (Kim et al. Neurology 70:2159–2165, 2008; Zhan et al. Hum Brain Mapp 30:874–882, 2009). However, methods for quantifying the existence and nature of such connections are vague and varied, and normative frequencies are inconsistent across studies. Therefore, the goals of the current study are twofold: (1) to develop a reliable method of identifying aTB sulci and their interconnections based on surface renderings generated from serial magnetic resonance images (MRIs). This protocol includes training materials and a rating log (see supplementary materials) that can be disseminated and applied by other researchers. (2) To determine the prevalence of interconnections among the three aTB sulci in a large sample of healthy adults (200 undergraduate students), which can be used as normative data for future comparison with clinical samples. Notably, the resulting protocol, called the Sulcal Classification Rating Protocol for anterior Temporobasal sulci, distinguishes “clear” from “ambiguous” connections. When only clear connections are included, our prevalence rates are consistent with post-mortem findings of Ono et al. (Atlas of the Cerebral Sulci. Thieme Medical Publishers, Inc., New York, 1990); when both clear and ambiguous connections are counted as a connection, our results largely replicate MRI-based findings (e.g., Kim et al. Neurology 70:2159–2165, 2008). We propose that systematic variations in rater classification of ambiguous connections could explain discrepancies in the literature.