Lack of efficacy for fluoxetine in PTSD: a placebo controlled trial in combat veterans.
Lack of efficacy for fluoxetine in PTSD: a placebo controlled trial in combat veterans.
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DOI：
10.3109/10401230009147096
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发表时间：
2000-06-01
期刊：
影响因子：
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通讯作者：
Davidson, J R
中科院分区：
文献类型：
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作者：
Hertzberg, M A;Feldman, M E;Davidson, J R
背景：氟西汀和安慰剂在患有严重、慢性创伤后应激障碍的退伍军人中进行了研究。方法：12名患有创伤后应激障碍的男性退伍军人参加了为期12周的氟西汀和安慰剂的双盲评估。结果：1名氟西汀患者有效(17%)，6名安慰剂患者(2名)有效(33%)。结论：在这一小样本患有严重、慢性创伤后应激障碍的男性退伍军人中，氟西汀患者没有表现出比安慰剂患者更好的反应。氟西汀在PTSD患者的对照研究中显示出有效的反应，这些患者主要是女性，遭受平民(非战斗)创伤，总体上经历的创伤后应激障碍不那么严重。在我们的研究中，氟西汀应答率低的原因尚不清楚，将等待进一步的研究，检查可能影响结果的症状以外的变量，如性别、合并症、既往治疗史、创伤类型、严重程度和慢性病。
BACKGROUND: Fluoxetine and placebo were studied in a population of combat veterans with severe, chronic PTSD.METHODS: Twelve male veterans with PTSD were enrolled in a 12 week double-blind evaluation of fluoxetine and placebo. Mean fluoxetine dose at endpoint (week 12) was 48 mg/day with a range of 10 mg to 60 mg.RESULTS: One fluoxetine patient responded (17%) and two of the six placebo patients responded (33%).CONCLUSIONS: Fluoxetine patients did not show a greater response than placebo patients in this small sample of male combat veterans with severe, chronic PTSD. Fluoxetine has displayed an efficacious response in controlled studies of patients with PTSD who were predominantly female, suffered civilian (noncombat) traumas, and were overall experiencing less severe PTSD. The reasons for the low response rate to fluoxetine in our study is unknown and will await further study examining variables other than symptoms that might influence outcome, such as gender, comorbidity, prior treatment history, trauma type, severity and chronicity.