Anticipated regret to increase uptake of colorectal cancer screening (ARTICS): A randomised controlled trial.
Anticipated regret to increase uptake of colorectal cancer screening (ARTICS): A randomised controlled trial.
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DOI：
10.1016/j.socscimed.2015.07.026
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Steele RJ
中科院分区：
文献类型：
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作者：
O'Carroll RE;Chambers JA;Brownlee L;Libby G;Steele RJ
筛查对于早期发现结直肠癌很重要。我们的目的是确定一个简单的预期后悔（AR）干预是否可以增加结直肠癌筛查的接受率。进行了一项随机对照试验，该试验采用简单的、基于药物的AR干预措施，并与现有的预先通知函一起提供。来自苏格兰国家筛查项目的60，000名年龄在50-74岁之间的成年人被随机分为以下组：（1）无问卷（对照），（2）健康控制点问卷（HISTORY）或（3）HISTORY + AR问卷。主要结局是愈创木粪隐血试验（FOBT）的恢复。次要结果包括归还检测试剂盒的意愿和感知厌恶（ICK）。共有59，366人被分配进行分析（意向治疗（ITT））;在FOBT摄取方面，治疗组之间没有观察到总体差异（对照组：57.3%，HALTH：56.9%，AR：57.4%）。共有13，645人（34.2%）返回了问卷。二次问卷测量的分析表明，AR通过意向间接影响FOBT摄取，而ICK直接影响FOBT摄取超过意向。AR对FOBT摄取的影响也受到意图强度的调节：仅对于不太强烈的意图，AR组的摄取率（84.6%）比障碍组（80.4%）高4.2%（差异的95% CI（2.0，6.5））。研究结果表明，包括AR和感知厌恶（ICK）的心理概念是决定FOBT摄取的重要因素。然而，在ITT分析中，AR干预没有简单的效果。可以得出结论，在那些低意图，暴露于AR可能需要增加FOBT摄取。当前对照试验见网站www.controlled-trials.com（编号：ISRCTN 74986452）。结直肠癌是全球死亡的主要原因;因此，筛查对于早期发现很重要。预期后悔（AR）可以导致筛查摄取的显着增加。一个简单的，基于虹膜的AR RCT干预在60，000名参与者中进行了测试。在ITT分析中未观察到AR干预对摄取的总体影响。AR强化了意图，并增加了那些意图较低的人的吸收。
Screening is important for early detection of colorectal cancer. Our aim was to determine whether a simple anticipated regret (AR) intervention could increase uptake of colorectal cancer screening. A randomised controlled trial of a simple, questionnaire-based AR intervention, delivered alongside existing pre-notification letters, was conducted. A total of 60,000 adults aged 50–74 years from the Scottish National Screening programme were randomised into the following groups: (1) no questionnaire (control), (2) Health Locus of Control questionnaire (HLOC) or (3) HLOC plus AR questionnaire. The primary outcome was return of the guaiac faecal occult blood test (FOBT). The secondary outcomes included intention to return test kit and perceived disgust (ICK). A total of 59,366 people were analysed as allocated (intention-to-treat (ITT)); no overall differences were seen between the treatment groups on FOBT uptake (control: 57.3%, HLOC: 56.9%, AR: 57.4%). In total, 13,645 (34.2%) individuals returned the questionnaires. Analysis of the secondary questionnaire measures showed that AR indirectly affected FOBT uptake via intention, whilst ICK directly affected FOBT uptake over and above intention. The effect of AR on FOBT uptake was also moderated by intention strength: for less-than-strong intenders only, uptake was 4.2% higher in the AR (84.6%) versus the HLOC group (80.4%) (95% CI for difference (2.0, 6.5)). The findings show that psychological concepts including AR and perceived disgust (ICK) are important factors in determining FOBT uptake. However, the AR intervention had no simple effect in the ITT analysis. It can be concluded that, in those with low intentions, exposure to AR may be required to increase FOBT uptake. The current controlled trials are presented at the website www.controlled-trials.com (number: ISRCTN74986452). Colorectal cancer is a major cause of deaths worldwide; hence, screening is important for early detection. Anticipated regret (AR) can lead to a significant increase in screening uptake. A simple, questionnaire-based AR RCT intervention was tested on 60,000 participants. No overall effect of the AR intervention on uptake was observed in the ITT analysis. AR strengthened intentions and increased uptake in those with low intentions.