The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin.
The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin.
复制标题
运动紧张素的氨基酸序列，一种从胃蛋白酶处理的人血浆中分离出来的新型肽：与人血清白蛋白、神经降压素和血管紧张素同源。
DOI：
10.1016/0006-291x(86)90429-8
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发表时间：
1986
影响因子：
3.1
通讯作者：
Walsh,JH
中科院分区：
文献类型：
--
作者：
Mogard,MH;Kobayashi,R;Chen,CF;Lee,TD;ReeveJr,JR;Shively,JE;Walsh,JH
用透析、离子交换层析和高效反相液相色谱从胃蛋白酶处理过的人血浆中分离得到一种新的具有神经紧张素样免疫反应性的九肽。通过自动气相序列分析确定氨基酸序列为Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu。与人血清白蛋白和生物活性肽神经降压素和血管紧张素的序列同源性被证明。这种肽被命名为kinetensin。
A novel nonapeptide with neurotensin-like immunoreactivity was isolated from pepsin-treated human plasma by dialysis, ion-exchange chromatography and high performance reversed-phase liquid chromatography. The amino acid sequence was determined by automated gas-phase sequence analysis as Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu. Sequence homology with human serum albumin and with the biologically active peptides neurotensin and angiotensin is demonstrated. The name proposed for this peptide is kinetensin.