High intake of cholesterol results in less atherogenic low-density lipoprotein particles in men and women independent of response classification
High intake of cholesterol results in less atherogenic low-density lipoprotein particles in men and women independent of response classification
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DOI：
10.1016/j.metabol.2003.12.030
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发表时间：
2004-06-01
影响因子：
9.8
通讯作者：
Fernandez, ML
中科院分区：
文献类型：
--
作者：
Herron, KL;Lofgren, IE;Fernandez, ML
高胆固醇饮食对低密度脂蛋白（LDL）颗粒致动脉粥样硬化性的影响通过测量LDL峰直径和组成、LDL对氧化的敏感性以及胆固醇在LDL亚类之间的分布来研究。交叉干预将27名绝经前女性和25名男性（18至50岁）随机分配到鸡蛋（640 mg/d额外膳食胆固醇）或安慰剂（0 mg/d额外膳食胆固醇）饮食30天，随后是3周的洗脱期。受试者被分类为对膳食胆固醇的高反应者（对于每消耗100 mg额外的膳食胆固醇，血浆胆固醇增加> 2.5 mg/dL）或低反应者。发现性别对检查的3个参数有显著影响。无论对饮食胆固醇的反应如何，女性LDL峰直径（26.78 +/- 0.59 nm，n = 27）显著大于男性（26.52 +/- 0.49 nm，n = 25）（P <0.005）。男性参与者的LDL颗粒中甘油三酯（TG）和胆固醇酯（CE）分子的数量也较高（P < .01）;然而，女性的胆固醇酯转移蛋白（CETP）活性较高（P < .05）。反应分类也揭示了LDL亚类测定的显着差异。与性别无关，LDL-1颗粒（P <0.05），被认为是动脉粥样硬化性较低，在高反应者中占主导地位，这一发现与胆固醇摄入量增加有关（交互作用，P <0.001）。此外，CETP和卵磷脂：胆固醇酰基转移酶（LCAT）的活动在卵期高反应（交互作用，P <0.05）。性别、对胆固醇摄入的反应和饮食不影响LDL对氧化的敏感性（P > 0.5）。由于LDL峰直径没有降低，并且在摄入鸡蛋后的高反应者中，较大的LDL-1亚类更大，因此这些数据表明，高胆固醇饮食的消耗不会对LDL颗粒的致动脉粥样硬化性产生负面影响。(C)2004年爱思唯尔公司All rights reserved.
The influence of a high-cholesterol diet on the atherogenicity of the low-density lipoprotein (LDL) particle was examined by measuring LDL peak diameter and composition, LDL susceptibility to oxidation, and the distribution of cholesterol between LDL subclasses. The crossover intervention randomly assigned 27 premenopausal women and 25 men (18 to 50 years) to an egg (640 mg/d additional dietary cholesterol) or placebo (0 mg/d additional dietary cholesterol) diet for 30 days, followed by a 3-week washout period. Subjects were classified as either hyperresponders ( > 2.5 mg/dL increase in plasma cholesterol for each 100 mg additional dietary cholesterol consumed) or hyporesponders to dietary cholesterol. Sex was found to have a significant effect on 3 of the parameters examined. LDL peak diameter was significantly larger (P < .005) in females (26.78 +/- 0.59 nm, n = 27) as compared with males (26.52 +/- 0.49 nm, n = 25), regardless of response to dietary cholesterol. The LDL particles of the male participants also had a higher number of triglyceride (TG) and cholesteryl ester (CE) molecules (P < .01); however, cholesterol ester transfer protein (CETP) activity was higher in females (P < .05). Response classification also revealed significant differences in the determination of LDL subclasses. Independent of sex, the LDL-1 particle (P < .05), which is considered to be less atherogenic, was predominant in hyperresponders and this finding was associated with increased cholesterol intake (interactive effect, P < .001). In addition, CETP and lecithin: cholesterol acyltransferase (LCAT) activities were higher in hyperresponders during the egg period (interactive effect, P < .05). Sex, response to cholesterol intake, and diet were not found to affect the susceptibility of LDL to oxidation (P > 0.5). Because LDL peak diameter was not decreased and the larger LDL-1 subclass was greater in hyperresponders following egg intake, these data indicate that the consumption of a high-cholesterol diet does not negatively influence the atherogenicity of the LDL particle. (C) 2004 Elsevier Inc. All rights reserved.